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Browsing MIT Open Access Articles by Author "Sive, Hazel L."

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Browsing MIT Open Access Articles by Author "Sive, Hazel L."

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  • Chang, Jessica T.; Sive, Hazel L. (MyJoVE Corporation, 2012-10)
    The brain ventricular system is conserved among vertebrates and is composed of a series of interconnected cavities called brain ventricles, which form during the earliest stages of brain development and are maintained ...
  • Ulitsky, Igor; Shkumatava, Alena; Jan, Calvin H.; Sive, Hazel L.; Bartel, David; Jan, Calvin H. (Elsevier B.V., 2011-12)
    Thousands of long intervening noncoding RNAs (lincRNAs) have been identified in mammals. To better understand the evolution and functions of these enigmatic RNAs, we used chromatin marks, poly(A)-site mapping and RNA-Seq ...
  • Sive, Hazel L.; Rienzo, Gianluca De; Gutzman, Jennifer H. (Mary Ann Liebert, 2012-07)
    Despite the broad repertoire of loss of function (LOF) tools available for use in the zebrafish, there remains a need for a simple and rapid method that can inhibit expression of genes at later stages. RNAi would fulfill ...
  • Gutzman, Jennifer H.; Sive, Hazel L. (Company of Biologists Ltd., 2010-03)
    We demonstrate that in the zebrafish hindbrain, cell shape, rhombomere morphogenesis and, unexpectedly, brain ventricle lumen expansion depend on the contractile state of the neuroepithelium. The hindbrain neural tube opens ...
  • Ulitsky, Igor; Shkumatava, Alena; Jan, Calvin H.; Subtelny, Alexander Orest; Koppstein, David Neal Pira; Bell, George W.; Sive, Hazel L.; Bartel, David P. (Cold Spring Harbor Laboratory Press, 2012-06)
    The post-transcriptional fate of messenger RNAs (mRNAs) is largely dictated by their 3′ untranslated regions (3′ UTRs), which are defined by cleavage and polyadenylation (CPA) of pre-mRNAs. We used poly(A)-position profiling ...
  • Jacox, Laura A.; Dickinson, Amanda J.; Sive, Hazel L. (MyJoVE Corporation, 2014-03)
    Craniofacial birth defects occur in 1 out of every 700 live births, but etiology is rarely known due to limited understanding of craniofacial development. To identify where signaling pathways and tissues act during patterning ...
  • Sive, Hazel L. (Springer Science + Business Media B.V., 2011)
    For two decades, my lab has been studying development using two vertebrate animals, the frog Xenopus and the zebrafish, Danio. This has been both productive and challenging. The initial rationale for the choice was to ...
  • Chang, Jessica T.; Sive, Hazel L. (MyJoVE Corporation, 2012-12)
    Cerebrospinal fluid (CSF) is a protein rich fluid contained within the brain ventricles. It is present during early vertebrate embryonic development and persists throughout life. Adult CSF is thought to cushion the brain, ...
  • Sawa, Akira; Korth, Carsten; Millar, J. Kirsty; Brandon, Nicholas J.; Singh, Karuna; Sive, Hazel L. (Society for Neuroscience, 2009-08)
    The biology of schizophrenia is complex with multiple hypotheses (dopamine, glutamate, neurodevelopmental) well supported to underlie the disease.Pathways centered on the risk factor “disrupted in schizophrenia1”(DISC1)maybe ...
  • Blaker-Lee, Alicia; Gupta, Sunny; McCammon, Jasmine M.; De Rienzo, Gianluca; Sive, Hazel L. (Company of Biologists, The, 2012-05)
    Deletion or duplication of one copy of the human 16p11.2 interval is tightly associated with impaired brain function, including autism spectrum disorders (ASDs), intellectual disability disorder (IDD) and other phenotypes, ...
  • Wardle, Fiona C; Odom, Duncan T; Bell, George W.; Wiellette, Elizabeth L; Herbolsheimer, Elizabeth; Smith, James C; Yuan, Bingbing B.; Sive, Hazel L.; Danford, Timothy William; Young, Richard A. (BioMed Central Ltd, 2006-08)
    We have designed a zebrafish genomic microarray to identify DNA-protein interactions in the proximal promoter regions of over 11,000 zebrafish genes. Using these microarrays, together with chromatin immunoprecipitation ...
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