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Browsing MIT Open Access Articles by Author "Sive, Hazel L."

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Efficient shRNA-Mediated Inhibition of Gene Expression in Zebrafish

Sive, Hazel L.; Rienzo, Gianluca De; Gutzman, Jennifer H. (Mary Ann Liebert, 2012-07)

Despite the broad repertoire of loss of function (LOF) tools available for use in the zebrafish, there remains a need for a simple and rapid method that can inhibit expression of genes at later stages. RNAi would fulfill ...
Epithelial Relaxation Mediated by the Myosin Phosphatase Regulator Mypt1 Is Required for Brain Ventricle Lumen Expansion and Hindbrain Morphogenesis

Gutzman, Jennifer H.; Sive, Hazel L. (Company of Biologists Ltd., 2010-03)

We demonstrate that in the zebrafish hindbrain, cell shape, rhombomere morphogenesis and, unexpectedly, brain ventricle lumen expansion depend on the contractile state of the neuroepithelium. The hindbrain neural tube opens ...
Extensive alternative polyadenylation during zebrafish development

Ulitsky, Igor; Shkumatava, Alena; Jan, Calvin H.; Subtelny, Alexander Orest; Koppstein, David Neal Pira; Bell, George W.; Sive, Hazel L.; Bartel, David P. (Cold Spring Harbor Laboratory Press, 2012-06)

The post-transcriptional fate of messenger RNAs (mRNAs) is largely dictated by their 3′ untranslated regions (3′ UTRs), which are defined by cleavage and polyadenylation (CPA) of pre-mRNAs. We used poly(A)-position profiling ...
Keeping two animal systems in one lab – a frog plus fish case study

Sive, Hazel L. (Springer Science + Business Media B.V., 2011)

For two decades, my lab has been studying development using two vertebrate animals, the frog Xenopus and the zebrafish, Danio. This has been both productive and challenging. The initial rationale for the choice was to ...
Understanding the Role of DISC1 in Psychiatric Disease and during Normal Development

Sawa, Akira; Korth, Carsten; Millar, J. Kirsty; Brandon, Nicholas J.; Singh, Karuna; Sive, Hazel L. (Society for Neuroscience, 2009-08)

The biology of schizophrenia is complex with multiple hypotheses (dopamine, glutamate, neurodevelopmental) well supported to underlie the disease.Pathways centered on the risk factor “disrupted in schizophrenia1”(DISC1)maybe ...
Zebrafish homologs of 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes

Blaker-Lee, Alicia; Gupta, Sunny; McCammon, Jasmine M.; De Rienzo, Gianluca; Sive, Hazel L. (Company of Biologists, The, 2012-05)

Deletion or duplication of one copy of the human 16p11.2 interval is tightly associated with impaired brain function, including autism spectrum disorders (ASDs), intellectual disability disorder (IDD) and other phenotypes, ...
Zebrafish promoter microarrays identify actively transcribed embryonic genes

Wardle, Fiona C; Odom, Duncan T; Bell, George W.; Wiellette, Elizabeth L; Herbolsheimer, Elizabeth; Smith, James C; Yuan, Bingbing B.; Sive, Hazel L.; Danford, Timothy William; Young, Richard A. (BioMed Central Ltd, 2006-08)

We have designed a zebrafish genomic microarray to identify DNA-protein interactions in the proximal promoter regions of over 11,000 zebrafish genes. Using these microarrays, together with chromatin immunoprecipitation ...

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Browsing MIT Open Access Articles by Author "Sive, Hazel L."

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