Search
Now showing items 1-10 of 23
Structural and dynamic basis of substrate permissiveness in hydroxycinnamoyltransferase (HCT)
(Public Library of Science (PLoS), 2018-10-26)
Substrate permissiveness has long been regarded as the raw materials for the evolution of new enzymatic functions. In land plants, hydroxycinnamoyltransferase (HCT) is an essential enzyme of the phenylpropanoid metabolism. ...
Role of Era in assembly and homeostasis of the ribosomal small subunit
(Oxford University Press (OUP), 2019-07)
Assembly factors provide speed and directionality to the maturation process of the 30S subunit in bacteria. To gain a more precise understanding of how these proteins mediate 30S maturation, it is important to expand on ...
Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging
(Elsevier BV, 2018-05)
Diet has a profound effect on tissue regeneration in diverse organisms, and low caloric states such as intermittent fasting have beneficial effects on organismal health and age-associated loss of tissue function. The role ...
Casting a wider net: Immunosurveillance by nonclassical MHC molecules
(Public Library of Science (PLoS), 2019-02-21)
Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological ...
A Bayesian model of acquisition and clearance of bacterial colonization incorporating within-host variation
(Public Library of Science (PLoS), 2019-04-22)
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Balance of mechanical forces drives endothelial gap formation and may facilitate cancer and immune-cell extravasation
(Public Library of Science (PLoS), 2019-05-02)
The formation of gaps in the endothelium is a crucial process underlying both cancer and immune cell extravasation, contributing to the functioning of the immune system during infection, the unfavorable development of ...
Energetics of optimal undulatory swimming organisms
(Public Library of Science (PLoS), 2019-10-31)
Energy consumption is one of the primary considerations in animal locomotion. In swimming locomotion, a number of questions related to swimming energetics of an organism and how the energetic quantities scale with body ...
Increased PHGDH expression promotes aberrant melanin accumulation
(Springer Science and Business Media LLC, 2019-07-22)
Background: Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas. Methods: In order ...
Sinorhizobium meliloti YbeY is a zinc-dependent single-strand specific endoribonuclease that plays an important role in 16S ribosomal RNA processing
(Oxford University Press (OUP), 2019-11-28)
Single-strand specific endoribonuclease YbeY has been shown to play an important role in the processing of the 3' end of the 16S rRNA in Escherichia coli. Lack of YbeY results in the accumulation of the 17S rRNA precursor. ...
MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer
(Cold Spring Harbor Laboratory, 2019-08-15)
Tumors display increased uptake and processing of nutrients to fulfill the demands of rapidly proliferating cancer cells. Seminal studies have shown that the proto-oncogene MYC promotes metabolic reprogramming by altering ...