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dc.contributor.authorKaufman, Alanen_US
dc.contributor.authorOrlin, James B., 1953-en_US
dc.date.accessioned2004-05-28T19:33:52Z
dc.date.available2004-05-28T19:33:52Z
dc.date.issued1994-08en_US
dc.identifier.urihttp://hdl.handle.net/1721.1/5326
dc.description.abstractCohen and colleagues [1] recently described a project to characterize a human yeast artificial chromosome (YAC) library and offered a 'proposed data analysis strategy' that was said to yield a physical map covering 87% of the human genome. The authors provided no analytical evaluation to test the validity of their novel strategy for constructing 'paths' in the genome. We have now examined the proposed method in detail. Analytical studies show that most paths with at most two YACs or spanning less than 5 cM are valid, but most paths involving four or more YACs or spanning 5 cM or more are invalid. After restricting the map to paths with a high probability of being valid, we conclude that the remaining map properly covers at most 36% of the genome.en_US
dc.format.extent463844 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherMassachusetts Institute of Technology, Operations Research Centeren_US
dc.relation.ispartofseriesOperations Research Center Working Paper;OR 295-94en_US
dc.titleAnalysis of a Proposed First Generation Physical Map of the Human Genomeen_US
dc.typeWorking Paperen_US


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