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Analysis of a Proposed First Generation Physical Map of the Human Genome

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dc.contributor.author Kaufman, Alan en_US
dc.contributor.author Orlin, James B., 1953- en_US
dc.date.accessioned 2004-05-28T19:33:52Z
dc.date.available 2004-05-28T19:33:52Z
dc.date.issued 1994-08 en_US
dc.identifier.uri http://hdl.handle.net/1721.1/5326
dc.description.abstract Cohen and colleagues [1] recently described a project to characterize a human yeast artificial chromosome (YAC) library and offered a 'proposed data analysis strategy' that was said to yield a physical map covering 87% of the human genome. The authors provided no analytical evaluation to test the validity of their novel strategy for constructing 'paths' in the genome. We have now examined the proposed method in detail. Analytical studies show that most paths with at most two YACs or spanning less than 5 cM are valid, but most paths involving four or more YACs or spanning 5 cM or more are invalid. After restricting the map to paths with a high probability of being valid, we conclude that the remaining map properly covers at most 36% of the genome. en_US
dc.format.extent 463844 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US en_US
dc.publisher Massachusetts Institute of Technology, Operations Research Center en_US
dc.relation.ispartofseries Operations Research Center Working Paper;OR 295-94 en_US
dc.title Analysis of a Proposed First Generation Physical Map of the Human Genome en_US
dc.type Working Paper en_US


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