Cermak, Nathan(Massachusetts Institute of Technology, 2017)
Single cells constitute a fundamental unit of biological organization, yet most laboratory techniques are unable to characterize single cell behavior and instead measure average properties of many thousands of cells. Among ...
Romer, Katherine A(Massachusetts Institute of Technology, 2016)
Mammalian spermatogenesis includes two types of cell divisions. First, germ cells undergo transit-amplifying mitotic divisions, which enable prodigious output of mature spermatozoa. Second, they undergo reductive meiotic ...
Gura Sadovsky, Rotem(Massachusetts Institute of Technology, 2016)
Whether at the level of a single protein, or in the cytoplasm as a whole, the diffusive mobility of proteins plays a key role in biological function. To measure protein diffusion in cells, researchers have developed multiple ...
Brock, Kelly Paige(Massachusetts Institute of Technology, 2016)
A protein's function in the cell depends on its structure, which in turn depends on the intracellular environment. Stress like heat shock or nutrient starvation can alter intracellular conditions, leading to protein ...
Willems, Thomas F. (Thomas Frederick)(Massachusetts Institute of Technology, 2016)
Over the past decade, the advent of next-generation DNA sequencing technologies has ushered in an exciting era of biological research. Through large-scale sequencing projects, scientists have begun to unveil the variability ...