Advanced Search
DSpace@MIT

Browsing Theses - Computational and Systems Biology by Title

Research and Teaching Output of the MIT Community

Browsing Theses - Computational and Systems Biology by Title

Sort by: Order: Results:

  • Measuring the effects of drugs on single cancer cell growth 
    Weng, Yaochung (Massachusetts Institute of Technology, 2012)
    Understanding the effectiveness of a drug therapy on halting disease progression is an essential aspect of cancer biology. Conventional assays that study cell behavior after a drug intervention report the average response ...
  • Mechanistic analysis of polymer-attached inhibitors of influenza virus and their effect on minimizing drug resistance 
    Lee, Chia Min (Jaimie Chia Min) (Massachusetts Institute of Technology, 2012)
    With the emergence of the 2009 A(H1N1) pandemic influenza virus and the rapid spread of drug resistance in recent years, the need to develop new anti-influenza drugs that can reduce the emergence of new resistant viruses ...
  • Molecular systems analysis of a cis-encoded epigenetic switch 
    Octavio, Leah M. (Leah Mae Manalo) (Massachusetts Institute of Technology, 2011)
    An ability to control the degree of heterogeneity in cellular phenotypes may be important for cell populations to survive uncertain and ever-changing environments or make cell-fate decisions in response to external stimuli. ...
  • Novel phylogenetic approaches to problems in microbial genomics 
    David, Lawrence A. (Lawrence Anthony) (Massachusetts Institute of Technology, 2010)
    Present day microbial genomes are the handiwork of over 3 billion years of evolution. Comparisons between these genomes enable stepping backwards through past evolutionary events, and can be formalized using binary tree ...
  • Origins of cell-to-cell variability in apoptosis 
    Spencer, Sabrina Leigh (Massachusetts Institute of Technology, 2009)
    Diversity within a population of organisms is typically ascribed to genetic differences. However, even members of a genetically identical group of cells or organisms in identical environments can exhibit variability in ...
  • The role of unfolded states in collagen degradation 
    Salsas Escat, Ramon (Massachusetts Institute of Technology, 2010)
    Excessive collagen degradation (collagenolysis) has been implicated in a series of diseases such as tumor metastasis, atherosclerosis and arthritis. There are still several unresolved questions about the mechanism of ...
  • Simultaneous computational discovery of DNA regulatory motifs and transcription factor binding constraints at high spatial resolution 
    Guo, Yuchun (Massachusetts Institute of Technology, 2012)
    I present three novel computational methods to address the challenge of identifying protein-DNA interactions at high spatial resolution from noisy ChIP-Seq data. I first present the genome positioning system (GPS) algorithm ...
  • The specificity and evolution of gene regulatory elements 
    Friedman, Robin Carl (Massachusetts Institute of Technology, 2010)
    The regulation of gene expression underlies the morphological, physiological, and functional differences between human cell types, developmental stages, and healthy and disease states. Gene regulation in eukaryotes is ...
  • A systems approach to uncovering the adaptive response of cancer to targeted therapies 
    Randall, Adrian Joseph (Massachusetts Institute of Technology, 2012)
    Tyrosine kinase inhibitors have significant promise in the fight to develop agents that can target cancer in a tumor-specific manner. A number of drugs have been and are currently in development to inhibit specific kinases ...
MIT-Mirage