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Browsing Theses - Computational and Systems Biology by Title

Research and Teaching Output of the MIT Community

Browsing Theses - Computational and Systems Biology by Title

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  • David, Lawrence A. (Lawrence Anthony) (Massachusetts Institute of Technology, 2010)
    Present day microbial genomes are the handiwork of over 3 billion years of evolution. Comparisons between these genomes enable stepping backwards through past evolutionary events, and can be formalized using binary tree ...
  • Spencer, Sabrina Leigh (Massachusetts Institute of Technology, 2009)
    Diversity within a population of organisms is typically ascribed to genetic differences. However, even members of a genetically identical group of cells or organisms in identical environments can exhibit variability in ...
  • Podgornaia, Anna Igorevna (Massachusetts Institute of Technology, 2014)
    Signal transduction pathways rely on transient yet specific protein-protein interactions. How a limited set of amino acids can enforce cognate protein interactions while excluding undesired pairings remains poorly understood, ...
  • Ashenberg, Orr (Massachusetts Institute of Technology, 2013)
    All cells sense and respond to their environments using signal transduction pathways. These pathways control a sweeping variety of cellular processes across the domains of life, but the pathways are often built from a ...
  • Salsas Escat, Ramon (Massachusetts Institute of Technology, 2010)
    Excessive collagen degradation (collagenolysis) has been implicated in a series of diseases such as tumor metastasis, atherosclerosis and arthritis. There are still several unresolved questions about the mechanism of ...
  • Guo, Yuchun (Massachusetts Institute of Technology, 2012)
    I present three novel computational methods to address the challenge of identifying protein-DNA interactions at high spatial resolution from noisy ChIP-Seq data. I first present the genome positioning system (GPS) algorithm ...
  • Al-Obeidi, Arshed (Massachusetts Institute of Technology, 2014)
    Caspases are a 12-member family of human proteases that regulate apoptosis and inflammation. They serve as key effectors downstream of diverse signaling receptors and shape cell fate. Inflammatory caspases mediate the ...
  • Friedman, Robin Carl (Massachusetts Institute of Technology, 2010)
    The regulation of gene expression underlies the morphological, physiological, and functional differences between human cell types, developmental stages, and healthy and disease states. Gene regulation in eukaryotes is ...
  • Randall, Adrian Joseph (Massachusetts Institute of Technology, 2012)
    Tyrosine kinase inhibitors have significant promise in the fight to develop agents that can target cancer in a tumor-specific manner. A number of drugs have been and are currently in development to inhibit specific kinases ...
  • Robertson, Alexander De Jong (Massachusetts Institute of Technology, 2014)
    Posttranscriptional regulation of mRNA by RNA-binding proteins plays key roles in regulating the transcriptome over the course of development, between tissues and in disease states. The specific interactions between mRNA ...
  • Park, Daniel K. (Daniel Kyu) (Massachusetts Institute of Technology, 2013)
    Understanding the cell as a system has become one of the foremost challenges in the post-genomic era. As a result of advances in high-throughput (HTP) methodologies, we have seen a rapid growth in new types of data at the ...
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