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Changes in the firing patterns in neurons of the sensorimotor striatum during learning : what changes and why

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dc.contributor.advisor Ann M. Graybiel. en_US
dc.contributor.author Barnes, Terra D. (Terra Diana) en_US
dc.contributor.other Massachusetts Institute of Technology. Dept. of Brain and Cognitive Sciences. en_US
dc.date.accessioned 2010-08-31T14:46:24Z
dc.date.available 2010-08-31T14:46:24Z
dc.date.copyright 2010 en_US
dc.date.issued 2010 en_US
dc.identifier.uri http://hdl.handle.net/1721.1/57795
dc.description Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2010. en_US
dc.description Cataloged from PDF version of thesis. en_US
dc.description Includes bibliographical references. en_US
dc.description.abstract The basal ganglia, and specifically the sensorimotor (dorsolateral) striatum, have been implicated in stimulus-response learning. Here, I analyze the role the striatum plays in learning. We recorded from neurons of the sensorimotor striatum as rats learn, are over-trained, are extinguished, and are re-trained on a discriminative T-maze task. In this T-maze a gate was lowered immediately after an auditory click and the rats were allowed to proceed down the long arm of the maze. Mid-run, one of two tones was played. Rats had to choose to turn down either the left or right arm of the T-maze based on which tone was played. We discovered that population neural activity becomes restructured during learning and overtraining to emphasize the beginning and end of each trial. We also created a short-term memory version of the T-maze task by moving the location of the tone cue in order to determine if this affects the strength of the restructuring seen in the firing patterns of the striatum as learning progressed. Lastly, we examined the relationship the training induced pattern had to learning the tone-turn association and to other things that changed systematically throughout learning, such as speed. en_US
dc.description.statementofresponsibility / by Terra D. Barnes. en_US
dc.format.extent 120 p. en_US
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.rights.uri http://dspace.mit.edu/handle/1721.1/7582 en_US
dc.subject Brain and Cognitive Sciences. en_US
dc.title Changes in the firing patterns in neurons of the sensorimotor striatum during learning : what changes and why en_US
dc.type Thesis en_US
dc.description.degree Ph.D. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Brain and Cognitive Sciences. en_US
dc.identifier.oclc 654100311 en_US


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