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The localization of mTORC1 signaling

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dc.contributor.advisor David M. Sabatini. en_US Peterson, Timothy Richard, Ph.D. Massachusetts Institute of Technology en_US
dc.contributor.other Massachusetts Institute of Technology. Dept. of Biology. en_US 2010-09-02T17:25:16Z 2010-09-02T17:25:16Z 2010 en_US 2010 en_US
dc.description Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2010. en_US
dc.description Cataloged from PDF version of thesis. en_US
dc.description Includes bibliographical references. en_US
dc.description.abstract Cells sense and respond to their environment by maintaining appropriate activity levels and localizations of key signaling proteins. In eukaryotic cells, cell size is increasingly appreciated as being coordinated by the Target of Rapamycin (TOR) Pathway. TOR is a serine/threonine kinase that resides in two distinct protein complexes which in mammals are referred to as mTORC1 and mTORC2. While significant emphasis has been placed on defining which pathways TOR controls and on how TOR activity is set, less is known about where TOR is positioned or positions its effectors to control growth. In the work described here, we identify and characterize three distinct aspects of the localization of mTORC1 signaling: the redistribution of the mTORC1 effectors, lipin 1 and SREBP, in controlling sterol- and lipogenesis; mTORC1- mediated regulation of actin-myosin contractility during cytokinesis; the regulation of mTORC1 localization in response to amino acids. Through these studies, we provide not only insights into the topology of cell growth, but also reveal how derangements of these localizations might contribute to conditions such as cancer and metabolic disease. en_US
dc.description.statementofresponsibility by Timothy Richard Peterson. en_US
dc.format.extent 208 p. en_US
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.rights.uri en_US
dc.subject Biology. en_US
dc.title The localization of mTORC1 signaling en_US
dc.type Thesis en_US Ph.D. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Biology. en_US
dc.identifier.oclc 654396316 en_US

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