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3D cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform

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3D cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform

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Alternative Title: Three-dimensional cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform
Author: Jeon, Jessie Sungyun
Other Contributors: Massachusetts Institute of Technology. Dept. of Mechanical Engineering.
Advisor: Joseph Charest and Roger Kamm.
Department: Massachusetts Institute of Technology. Dept. of Mechanical Engineering.
Publisher: Massachusetts Institute of Technology
Date Issued: 2010
Abstract:
A microfluidic system has been developed for studying the factors inducing different responses of cells in vascular system using a three-dimensional microenvironment. The devices have been transferred from PDMS to a platform in cyclic olefin copolymer (COC) which has advantages in terms of hydrophobicity, production by the more commercially-viable hot embossing technique, and amenability to surface treatments. Here the fabrication process is described and the new systems are characterized. Surface wettability, bond strength between the system body and a covering plastic film, and cell viability data are presented and compared to systems fabricated in PDMS.
Description:
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010.Cataloged from PDF version of thesis.Includes bibliographical references (p. 48-51).
URI: http://hdl.handle.net/1721.1/61871
Keywords: Mechanical Engineering.

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