Nuclear Factor I/B is an Oncogene in Small Cell Lung Cancer
Author(s)Dooley, Alison L.; Winslow, Monte Meier; Chiang, Derek Y.; Banerji, Shantanu; Stransky, Nicolas; Dayton, Talya Lucia; Snyder, Eric; Senna, Stephanie; Whittaker, Charles A.; Bronson, Roderick T.; Crowley, Denise G.; Barretina, Jordi; Garraway, Levi A.; Meyerson, Matthew L.; Jacks, Tyler E.; ... Show more Show less
MetadataShow full item record
Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels. Using a genetically engineered mouse model of SCLC driven by conditional deletion of Trp53 and Rb1 in the lung, we identified several frequent, high-magnitude focal DNA copy number alterations in SCLC. We uncovered amplification of a novel, oncogenic transcription factor, Nuclear factor I/B (Nfib), in the mouse SCLC model and in human SCLC. Functional studies indicate that NFIB regulates cell viability and proliferation during transformation.
DepartmentBroad Institute of MIT and Harvard; David H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Biology
Genes and Development
Cold Spring Harbor Laboratory Press in association with The Genetics Society
Dooley, A. L. et al. “Nuclear factor I/B is an oncogene in small cell lung cancer.” Genes & Development 25 (2011): 1470-1475.
Author's final manuscript