Advanced Search

In vivo lumbar spine biomechanics : vertebral kinematics, intervertebral disc deformation, and disc loads

Research and Teaching Output of the MIT Community

Show simple item record

dc.contributor.advisor Guoan Li. en_US Wang, Shaobai en_US
dc.contributor.other Massachusetts Institute of Technology. Dept. of Mechanical Engineering. en_US 2012-04-26T18:52:42Z 2012-04-26T18:52:42Z 2012 en_US 2012 en_US
dc.description Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2012. en_US
dc.description Cataloged from PDF version of thesis. en_US
dc.description Includes bibliographical references. en_US
dc.description.abstract Knowledge of lumbar spine biomechanics in living human subjects is fundamental for understanding mechanisms of spinal injury and pathology, for improvement of corresponding clinical treatments, and for design of spinal prosthesis. However, due to the complicated spine anatomy and loading conditions as well as high risks in these direct measurements, it has been a challenge to determine the in vivo biomechanics of the lumbar spine. To address this problem, the overall objective of this thesis was to develop and implement a dual fluoroscopic imaging system to non-invasively study human lumbar spine biomechanics. In line with this objective, the first goal was to quantify the ability of the dual fluoroscopic imaging system to determine vertebral kinematics. The second goal was to implement this technique to investigate spinal motion in both healthy subjects and patients with pathology. The third goal was to explore the feasibility of using kinematic data obtained from this system as boundary conditions in finite element analysis to calculate the physiological loads on the intervertebral disc. The system was shown to be accurate and repeatable in determining the vertebral kinematics in all degrees of freedom. For the first time, six degree-of-freedom motion of different structures of the spine, such as the vertebral body, intervertebral disc, facet joint and spinous process were measured in vivo in both healthy subjects and subjects with pathology during functional activities. In general, the group of subjects with pathology showed a significantly abnormal kinematic response during various physiological functional activities. Preliminary studies have shown the applicability and high accuracy of finite element modeling to calculate disc loads using in vivo vertebral kinematics as displacement boundary conditions. en_US
dc.description.statementofresponsibility by Shaobai Wang. en_US
dc.format.extent 271 p. en_US
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.rights.uri en_US
dc.subject Mechanical Engineering. en_US
dc.title In vivo lumbar spine biomechanics : vertebral kinematics, intervertebral disc deformation, and disc loads en_US
dc.type Thesis en_US Ph.D. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Mechanical Engineering. en_US
dc.identifier.oclc 785212887 en_US

Files in this item

Name Size Format Description
785212887-MIT.pdf 27.82Mb PDF Full printable version

This item appears in the following Collection(s)

Show simple item record