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Habit learning is associated with major shifts in frequencies of oscillatory activity and synchronized spike firing in striatum

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dc.contributor.author Howe, Mark William
dc.contributor.author Atallah, Hicham
dc.contributor.author McCool, Andrew D.
dc.contributor.author Gibson, Daniel J.
dc.contributor.author Graybiel, Ann M.
dc.date.accessioned 2012-05-24T15:34:06Z
dc.date.available 2012-05-24T15:34:06Z
dc.date.issued 2011-10
dc.date.submitted 2011-08
dc.identifier.issn 0027-8424
dc.identifier.issn 1091-6490
dc.identifier.uri http://hdl.handle.net/1721.1/70923
dc.description.abstract Rhythmic brain activity is thought to reflect, and to help organize, spike activity in populations of neurons during on-going behavior. We report that during learning, a major transition occurs in task-related oscillatory activity in the ventromedial striatum, a striatal region related to motivation-dependent learning. Early on as rats learned a T-maze task, bursts of 70- to 90-Hz high-γ activity were prominent during T-maze runs, but these gradually receded as bursts of 15- to 28-Hz β-band activity became pronounced. Populations of simultaneously recorded neurons synchronized their spike firing similarly during both the high-γ–band and β-band bursts. Thus, the structure of spike firing was reorganized during learning in relation to different rhythms. Spiking was concentrated around the troughs of the β-oscillations for fast-spiking interneurons and around the peaks for projection neurons, indicating alternating periods of firing at different frequencies as learning progressed. Spike-field synchrony was primarily local during high-γ–bursts but was widespread during β-bursts. The learning-related shift in the probability of high-γ and β-bursting thus could reflect a transition from a mainly focal rhythmic inhibition during early phases of learning to a more distributed mode of rhythmic inhibition as learning continues and behavior becomes habitual. These dynamics could underlie changing functions of the ventromedial striatum during habit formation. More generally, our findings suggest that coordinated changes in the spatiotemporal relationships of local field potential oscillations and spike activity could be hallmarks of the learning process. en_US
dc.description.sponsorship National Institutes of Health (U.S.) (Grant R01 MH060379) en_US
dc.description.sponsorship Mark Gorenberg Graduate Student Fellowship Award en_US
dc.language.iso en_US
dc.publisher National Academy of Sciences (U.S.) en_US
dc.relation.isversionof http://dx.doi.org/10.1073/pnas.1113158108 en_US
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. en_US
dc.source PNAS en_US
dc.title Habit learning is associated with major shifts in frequencies of oscillatory activity and synchronized spike firing in striatum en_US
dc.type Article en_US
dc.identifier.citation Howe, M. W. et al. “Habit Learning Is Associated with Major Shifts in Frequencies of Oscillatory Activity and Synchronized Spike Firing in Striatum.” Proceedings of the National Academy of Sciences 108.40 (2011): 16801–16806. Web. en_US
dc.contributor.department Massachusetts Institute of Technology. Office of the Institute Professors en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Brain and Cognitive Sciences en_US
dc.contributor.department McGovern Institute for Brain Research at MIT en_US
dc.contributor.approver Graybiel, Ann M.
dc.contributor.mitauthor Graybiel, Ann M.
dc.contributor.mitauthor Howe, Mark William
dc.contributor.mitauthor Atallah, Hicham
dc.contributor.mitauthor McCool, Andrew D.
dc.contributor.mitauthor Gibson, Daniel J.
dc.relation.journal Proceedings of the National Academy of Sciences of the United States of America en_US
dc.identifier.mitlicense PUBLISHER_POLICY en_US
dc.eprint.version Final published version en_US
dc.type.uri http://purl.org/eprint/type/JournalArticle en_US
eprint.status http://purl.org/eprint/status/PeerReviewed en_US
dspace.orderedauthors Howe, M. W.; Atallah, H. E.; McCool, A.; Gibson, D. J.; Graybiel, A. M. en


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