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Towards a carbon nanotube antibody sensor

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dc.contributor.advisor Michael Strano. en_US Bojö, Peter en_US
dc.contributor.other Massachusetts Institute of Technology. Dept. of Biological Engineering. en_US 2012-07-02T15:43:14Z 2012-07-02T15:43:14Z 2011 en_US 2012 en_US
dc.description Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, February 2012. en_US
dc.description Cataloged from PDF version of thesis. en_US
dc.description Includes bibliographical references (p. 46-51). en_US
dc.description.abstract This work investigated single-walled carbon nanotube (SWNT)/polymer-protein A complexes for optically reporting antibody concentration via a change in near infrared fluorescent emission after antibody binding. SWNT have potential as biosensors because of extraordinary sensitivity, lack of photobleaching, and optical activity in a near-infrared window. A SWNT sensor could provide label-free measurements of antibody concentration in a continuous fashion, which may aid selection of production strains. Protein A itself, dextran, poly vinyl alcohol, DNA sequences, and chitosan were used as polymers for wrapping SWNT. Nonspecific binding to solution-phase constructs was found to be a major problem with these approaches. Chitosan hydrogels encapsulating SWNT also show nonspecific responses. en_US
dc.description.statementofresponsibility by Peter Bojö. en_US
dc.format.extent 51 p. en_US
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. en_US
dc.rights.uri en_US
dc.subject Biological Engineering. en_US
dc.title Towards a carbon nanotube antibody sensor en_US
dc.type Thesis en_US M.Eng. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Biological Engineering. en_US
dc.identifier.oclc 795184338 en_US

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