Towards a carbon nanotube antibody sensor
Research and Teaching Output of the MIT Community
JavaScript is disabled for your browser. Some features of this site may not work without it.
| dc.contributor.advisor | Michael Strano. | en_US |
| dc.contributor.author | Bojö, Peter | en_US |
| dc.contributor.other | Massachusetts Institute of Technology. Dept. of Biological Engineering. | en_US |
| dc.date.accessioned | 2012-07-02T15:43:14Z | |
| dc.date.available | 2012-07-02T15:43:14Z | |
| dc.date.copyright | 2011 | en_US |
| dc.date.issued | 2012 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1721.1/71463 | |
| dc.description | Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, February 2012. | en_US |
| dc.description | Cataloged from PDF version of thesis. | en_US |
| dc.description | Includes bibliographical references (p. 46-51). | en_US |
| dc.description.abstract | This work investigated single-walled carbon nanotube (SWNT)/polymer-protein A complexes for optically reporting antibody concentration via a change in near infrared fluorescent emission after antibody binding. SWNT have potential as biosensors because of extraordinary sensitivity, lack of photobleaching, and optical activity in a near-infrared window. A SWNT sensor could provide label-free measurements of antibody concentration in a continuous fashion, which may aid selection of production strains. Protein A itself, dextran, poly vinyl alcohol, DNA sequences, and chitosan were used as polymers for wrapping SWNT. Nonspecific binding to solution-phase constructs was found to be a major problem with these approaches. Chitosan hydrogels encapsulating SWNT also show nonspecific responses. | en_US |
| dc.description.statementofresponsibility | by Peter Bojö. | en_US |
| dc.format.extent | 51 p. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Massachusetts Institute of Technology | en_US |
| dc.rights | M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. | en_US |
| dc.rights.uri | http://dspace.mit.edu/handle/1721.1/7582 | en_US |
| dc.subject | Biological Engineering. | en_US |
| dc.title | Towards a carbon nanotube antibody sensor | en_US |
| dc.type | Thesis | en_US |
| dc.description.degree | M.Eng. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Dept. of Biological Engineering. | en_US |
| dc.identifier.oclc | 795184338 | en_US |
Files in this item
| Name | Size | Format | Description |
|---|---|---|---|
| 795184338.pdf | 10.95Mb | Preview, non-printable (open to all) | |
| 795184338-MIT.pdf | 10.95Mb | Full printable version (MIT only) |
This item appears in the following Collection(s)
Browse
My Account
MIT-Mirage