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Web servers, databases, and algorithms for the analysis of protein interaction networks
(Massachusetts Institute of Technology, 2013)
Understanding the cell as a system has become one of the foremost challenges in the post-genomic era. As a result of advances in high-throughput (HTP) methodologies, we have seen a rapid growth in new types of data at the ...
Defining the molecular basis for the β-catenin and CDC73 interaction
(Massachusetts Institute of Technology, 2022-05)
RNA polymerase II (Pol II) is required for expression of protein coding genes. To initiate gene transcription, Pol II is recruited to gene promoters by transcription factors. Gene specific transcription factors, including ...
A systems approach to uncovering the adaptive response of cancer to targeted therapies
(Massachusetts Institute of Technology, 2012)
Tyrosine kinase inhibitors have significant promise in the fight to develop agents that can target cancer in a tumor-specific manner. A number of drugs have been and are currently in development to inhibit specific kinases ...
Single-cell reporters for inflammatory caspase activity
(Massachusetts Institute of Technology, 2014)
Caspases are a 12-member family of human proteases that regulate apoptosis and inflammation. They serve as key effectors downstream of diverse signaling receptors and shape cell fate. Inflammatory caspases mediate the ...
Analysis of coordinated skipped exon pairs using single molecule sequencing technology
(Massachusetts Institute of Technology, 2014)
Alternative splicing of mRNA transcripts is a significant step in the production of functioning protein. This process is a major source of molecular diversity, as numerous mRNA and protein products can arise from a single ...
Strain-resolved transcriptomics: exploring functional heterogeneity of the gut microbiota in health and disease
(Massachusetts Institute of Technology, 2025-09)
The gut microbiome plays a critical role in inflammatory bowel diseases (IBDs), yet current analyses treat bacterial species as functionally uniform, ignoring extensive strain-level diversity that may drive disease mechanisms. ...