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Physical and biological properties of a Pt(ll) complex of a beta-diketiminate ligand with pendant quinoline arms

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dc.contributor.advisor Stephen J. Lippard. en_US
dc.contributor.author Hope, Jennifer M en_US
dc.contributor.other Massachusetts Institute of Technology. Dept. of Chemistry. en_US
dc.date.accessioned 2012-09-27T15:28:04Z
dc.date.available 2012-09-27T15:28:04Z
dc.date.copyright 2012 en_US
dc.date.issued 2012 en_US
dc.identifier.uri http://hdl.handle.net/1721.1/73389
dc.description Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2012. en_US
dc.description Cataloged from PDF version of thesis. en_US
dc.description Includes bibliographical references (p. 55-56). en_US
dc.description.abstract A monoanionic, tetradentate [beta]-diketiminate (BDI) ligand with pendant quinoline arms, BDIQQH was coordinated to Pt(II) to yield the square-planar complex [Pt(BDIQQ)]CI. This complex was characterized by NMR spectroscopy, ESI-MS, FTIR spectroscopy, UVVisible absorbance spectroscopy, and cyclic voltammetry. Computational studies, including geometry optimizations and frequency calculations, were carried out to further analyze the electronic structures of the complexes. In addition, the DNA-binding properties of the complexes were evaluated by UV-Vis titrations and an ethidium-bromide displacement assay. Our results indicate that the compounds interact with DNA, although the mode of interaction is still ambiguous. Fluorescence studies were also performed to investigate the interaction of the complex with bovine serum albumin (BSA) as a model protein. Finally, cytotoxicity data were obtained in a small panel of cell lines using the MTT assay. The complex has a toxicity comparable to or higher than that of cisplatin in the lines tested. en_US
dc.description.statementofresponsibility by Jennifer M. Hope. en_US
dc.format.extent 56 p. en_US
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.rights.uri http://dspace.mit.edu/handle/1721.1/7582 en_US
dc.subject Chemistry. en_US
dc.title Physical and biological properties of a Pt(ll) complex of a beta-diketiminate ligand with pendant quinoline arms en_US
dc.type Thesis en_US
dc.description.degree S.B. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Chemistry. en_US
dc.identifier.oclc 809805015 en_US


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