Advanced Search
DSpace@MIT

Discovering Regulatory Overlapping RNA Transcripts

Research and Teaching Output of the MIT Community

Show simple item record

dc.contributor.author Danford, Timothy
dc.contributor.author Dowell, Robin D.
dc.contributor.author Agarwala, Sundeep
dc.contributor.author Grisafi, Paula
dc.contributor.author Fink, Gerald R.
dc.contributor.author Gifford, David K.
dc.date.accessioned 2012-10-09T17:25:47Z
dc.date.available 2012-10-09T17:25:47Z
dc.date.issued 2010-05
dc.date.submitted 2010-04
dc.identifier.isbn 978-3-642-12682-6
dc.identifier.issn 0302-9743
dc.identifier.issn 1611-3349
dc.identifier.uri http://hdl.handle.net/1721.1/73688
dc.description.abstract STEREO is a novel algorithm that discovers cis-regulatory RNA interactions by assembling complete and potentially overlapping same-strand RNA transcripts from tiling expression data. STEREO first identifies coherent segments of transcription and then discovers individual transcripts that are consistent with the observed segments given intensity and shape constraints. We used STEREO to identify 1446 regions of overlapping transcription in two strains of yeast, including transcripts that comprise a new form of molecular toggle switch that controls gene variegation. en_US
dc.language.iso en_US
dc.publisher Springer Berlin/Heidelberg en_US
dc.relation.isversionof http://dx.doi.org/ 10.1007/978-3-642-12683-3_8 en_US
dc.rights Creative Commons Attribution-Noncommercial-Share Alike 3.0 en_US
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/ en_US
dc.source MIT web domain en_US
dc.title Discovering Regulatory Overlapping RNA Transcripts en_US
dc.type Article en_US
dc.identifier.citation Danford, Timothy et al. “Discovering Regulatory Overlapping RNA Transcripts.” Research in Computational Molecular Biology. Ed. Bonnie Berger. LNCS Vol. 6044. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. 110-122. en_US
dc.contributor.department Massachusetts Institute of Technology. Department of Biology en_US
dc.contributor.department Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science en_US
dc.contributor.department Whitehead Institute for Biomedical Research en_US
dc.contributor.mitauthor Danford, Timothy
dc.contributor.mitauthor Dowell, Robin D.
dc.contributor.mitauthor Agarwala, Sundeep
dc.contributor.mitauthor Grisafi, Paula
dc.contributor.mitauthor Fink, Gerald R.
dc.contributor.mitauthor Gifford, David K.
dc.relation.journal Research in Computational Molecular Biology en_US
dc.identifier.mitlicense OPEN_ACCESS_POLICY en_US
dc.eprint.version Author's final manuscript en_US
dc.type.uri http://purl.org/eprint/type/ConferencePaper en_US
dspace.orderedauthors Danford, Timothy; Dowell, Robin; Agarwala, Sudeep; Grisafi, Paula; Fink, Gerald; Gifford, David en


Files in this item

Name Size Format
Downloadable Full Text - PDF

This item appears in the following Collection(s)

Show simple item record

Creative Commons Attribution-Noncommercial-Share Alike 3.0 Except where otherwise noted, this item's license is described as Creative Commons Attribution-Noncommercial-Share Alike 3.0
Open Access