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Characterization of cardiac lead perforation risk via a dynamic simulated environment

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dc.contributor.advisor Alexander H. Slocum. en_US
dc.contributor.author Rosario, Matthew J en_US
dc.contributor.other Massachusetts Institute of Technology. Dept. of Mechanical Engineering. en_US
dc.date.accessioned 2012-10-10T15:47:08Z
dc.date.available 2012-10-10T15:47:08Z
dc.date.copyright 2012 en_US
dc.date.issued 2012 en_US
dc.identifier.uri http://hdl.handle.net/1721.1/73806
dc.description Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2012. en_US
dc.description Cataloged from PDF version of thesis. en_US
dc.description Includes bibliographical references (p. 102-103). en_US
dc.description.abstract Delayed cardiac perforation is a serious medical condition where an implanted cardiac lead migrates through the heart wall, causing life-threatening complications. Where acute perforation occurs during implant, delayed perforation is not detected until after 30 days from implant and is frequently not diagnosed until complications are present. The phenomenon is particularly prevalent in cardiac leads with active helices. Detailed here is a test method that subjects leads to cyclic loading in an environment similar to that of the human heart. A test setup was developed; leads migrate through a degradable cardiac simulant for a fixed cycle count, after which the simulant is evaluated. Initial testing was conducted and improvements made to the device. Nineteen cardiac lead models were tested and ranked in three metrics related to perforation damage. Trends matched available medical knowledge on lead perforation risk. This experiment provides a framework for further investigation into lead perforation. en_US
dc.description.statementofresponsibility by Matthew J. Rosario. en_US
dc.format.extent 109 p. en_US
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.rights.uri http://dspace.mit.edu/handle/1721.1/7582 en_US
dc.subject Mechanical Engineering. en_US
dc.title Characterization of cardiac lead perforation risk via a dynamic simulated environment en_US
dc.type Thesis en_US
dc.description.degree S.M. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Mechanical Engineering. en_US
dc.identifier.oclc 811142262 en_US


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MIT-Mirage