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The landscape of somatic copy-number alteration across human cancers

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dc.contributor.author Lander, Eric S.
dc.date.accessioned 2012-10-12T18:31:53Z
dc.date.available 2012-10-12T18:31:53Z
dc.date.issued 2010-02
dc.identifier.issn 0028-0836
dc.identifier.issn 1476-4687
dc.identifier.uri http://hdl.handle.net/1721.1/73943
dc.description available in PMC 2010 August 18. en_US
dc.description.abstract A powerful way to discover key genes with causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers. Here we present high-resolution analyses of somatic copy-number alterations (SCNAs) from 3,131 cancer specimens, belonging largely to 26 histological types. We identify 158 regions of focal SCNA that are altered at significant frequency across several cancer types, of which 122 cannot be explained by the presence of a known cancer target gene located within these regions. Several gene families are enriched among these regions of focal SCNA, including the BCL2 family of apoptosis regulators and the NF-κΒ pathway. We show that cancer cells containing amplifications surrounding the MCL1 and BCL2L1 anti-apoptotic genes depend on the expression of these genes for survival. Finally, we demonstrate that a large majority of SCNAs identified in individual cancer types are present in several cancer types. en_US
dc.description.sponsorship National Institutes of Health (U.S.) (Dana-Farber/Harvard Cancer Center and Pacific Northwest Prostate Cancer SPOREs, P50CA90578) en_US
dc.description.sponsorship National Institutes of Health (U.S.) (Dana-Farber/Harvard Cancer Center and Pacific Northwest Prostate Cancer SPOREs, R01CA109038)) en_US
dc.description.sponsorship National Institutes of Health (U.S.) (Dana-Farber/Harvard Cancer Center and Pacific Northwest Prostate Cancer SPOREs, R01CA109467) en_US
dc.description.sponsorship National Institutes of Health (U.S.) (Dana-Farber/Harvard Cancer Center and Pacific Northwest Prostate Cancer SPOREs, P01CA085859) en_US
dc.description.sponsorship National Institutes of Health (U.S.) (Dana-Farber/Harvard Cancer Center and Pacific Northwest Prostate Cancer SPOREs, P01CA 098101) en_US
dc.description.sponsorship National Institutes of Health (U.S.) (Dana-Farber/Harvard Cancer Center and Pacific Northwest Prostate Cancer SPOREs, K08CA122833) en_US
dc.language.iso en_US
dc.publisher Nature Publishing Group en_US
dc.relation.isversionof http://dx.doi.org/10.1038/nature08822 en_US
dc.rights Creative Commons Attribution-Noncommercial-Share Alike 3.0 en_US
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/ en_US
dc.source PMC en_US
dc.title The landscape of somatic copy-number alteration across human cancers en_US
dc.type Article en_US
dc.identifier.citation Beroukhim, Rameen et al. “The Landscape of Somatic Copy-number Alteration Across Human Cancers.” Nature 463.7283 (2010): 899–905. Web. en_US
dc.contributor.department Whitehead Institute for Biomedical Research en_US
dc.contributor.department Massachusetts Institute of Technology. Department of Biology en_US
dc.contributor.mitauthor Lander, Eric S.
dc.relation.journal Nature en_US
dc.identifier.mitlicense OPEN_ACCESS_POLICY en_US
dc.eprint.version Author's final manuscript en_US
dc.type.uri http://purl.org/eprint/type/JournalArticle en_US
eprint.status http://purl.org/eprint/status/PeerReviewed en_US
dspace.orderedauthors Beroukhim, Rameen; Mermel, Craig H.; Porter, Dale; Wei, Guo; Raychaudhuri, Soumya; Donovan, Jerry; Barretina, Jordi; Boehm, Jesse S.; Dobson, Jennifer; Urashima, Mitsuyoshi; Mc Henry, Kevin T.; Pinchback, Reid M.; Ligon, Azra H.; Cho, Yoon-Jae; Haery, Leila; Greulich, Heidi; Reich, Michael; Winckler, Wendy; Lawrence, Michael S.; Weir, Barbara A.; Tanaka, Kumiko E.; Chiang, Derek Y.; Bass, Adam J.; Loo, Alice; Hoffman, Carter; Prensner, John; Liefeld, Ted; Gao, Qing; Yecies, Derek; Signoretti, Sabina; Maher, Elizabeth; Kaye, Frederic J.; Sasaki, Hidefumi; Tepper, Joel E.; Fletcher, Jonathan A.; Tabernero, Josep; Baselga, José; Tsao, Ming-Sound; Demichelis, Francesca; Rubin, Mark A.; Janne, Pasi A.; Daly, Mark J.; Nucera, Carmelo; Levine, Ross L.; Ebert, Benjamin L.; Gabriel, Stacey; Rustgi, Anil K.; Antonescu, Cristina R.; Ladanyi, Marc; Letai, Anthony; Garraway, Levi A.; Loda, Massimo; Beer, David G.; True, Lawrence D.; Okamoto, Aikou; Pomeroy, Scott L.; Singer, Samuel; Golub, Todd R.; Lander, Eric S.; Getz, Gad; Sellers, William R.; Meyerson, Matthew en


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