| dc.contributor.author | Efeyan, Alejo | |
| dc.contributor.author | Sabatini, David | |
| dc.date.accessioned | 2012-11-01T16:42:06Z | |
| dc.date.available | 2012-11-01T16:42:06Z | |
| dc.date.issued | 2009-04 | |
| dc.identifier.issn | 0955-0674 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/74543 | |
| dc.description.abstract | The mammalian target of rapamycin (mTOR) is a master regulator of cell growth and division that responds to a variety of stimuli, including nutrient, energy, and growth factors. In the last years, a significant number of pieces have been added to the puzzle of how mTOR coordinates and executes its functions. Extensive research on mTOR has also uncovered a complex network of regulatory loops that impact the therapeutic approaches aimed at targeting mTOR. | en_US |
| dc.description.sponsorship | Howard Hughes Medical Institute | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) | en_US |
| dc.description.sponsorship | Human Frontier Science Program (Strasbourg, France) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Elsevier | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1016/j.ceb.2009.10.007 | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike 3.0 | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/ | en_US |
| dc.source | PMC | en_US |
| dc.title | mTOR and cancer: many loops in one pathway | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Efeyan, Alejo, and David M Sabatini. “mTOR and Cancer: Many Loops in One Pathway.” Current Opinion in Cell Biology 22.2 (2010): 169–176. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
| dc.contributor.department | Whitehead Institute for Biomedical Research | en_US |
| dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
| dc.contributor.mitauthor | Efeyan, Alejo | |
| dc.contributor.mitauthor | Sabatini, David M. | |
| dc.relation.journal | Current Opinion in Cell Biology | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Efeyan, Alejo; Sabatini, David M | en |
| dc.identifier.orcid | https://orcid.org/0000-0002-1446-7256 | |
| mit.license | OPEN_ACCESS_POLICY | en_US |
| mit.metadata.status | Complete | |
