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Fabrication of Controlled Release Devices Using Supercritical Antisolvent Method

Research and Teaching Output of the MIT Community

Show simple item record Lee, Lai Yeng Smith, Kenneth A. Wang, Chi-Hwa 2004-12-15T20:10:45Z 2004-12-15T20:10:45Z 2005-01
dc.description.abstract In this study, the supercritical antisolvent with enhanced mass transfer method (SASEM) is used to fabricate micro and nanoparticles of biocompatible and biodegradable polymer PLGA (poly DL lactide co glycolic acid). This process may be extended to the encapsulation of drugs in these micro and nanoparticles for controlled release purposes. Conventional supercritical antisolvent (SAS) process involves spraying a solution (organic solvent + dissolved polymer) into supercritical fluid (CO[subscript 2]), which acts as an antisolvent. The high rate of mass transfer between organic solvent and supercritical CO[subscript 2] results in supersaturation of the polymer in the spray droplet and precipitation of the polymer as micro or nanoparticles occurs. In the SASEM method, ultrasonic vibration is used to atomize the solution entering the high pressure with supercritical CO[subscript 2]. At the same time, the ultrasonic vibration generated turbulence in the high pressure vessel, leading to better mass transfer between the organic solvent and the supercritical CO₂. In this study, two organic solvents, acetone and dichloromethane (DCM) were used in the SASEM process. Phase Doppler Particle Analyzer (PDPA) was used to study the ultrasonic atomization of liquid using the ultrasonic probe for the SASEM process. Scanning Electron Microscopy (SEM) was used to study the size and morphology of the polymer particles collected at the end of the process. en
dc.description.sponsorship Singapore-MIT Alliance (SMA) en
dc.format.extent 618470 bytes
dc.format.mimetype application/pdf
dc.language.iso en
dc.relation.ispartofseries Molecular Engineering of Biological and Chemical Systems (MEBCS);
dc.subject Supercritical antisolvent en
dc.subject Ultrasonic liquid atomization en
dc.subject controlled release en
dc.subject PLGA (poly DL lactic co glycolic acid) en
dc.subject CO2 en
dc.title Fabrication of Controlled Release Devices Using Supercritical Antisolvent Method en
dc.type Article en

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