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Intradermal needle-free powdered drug injection

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dc.contributor.advisor Ian W. Hunter. en_US
dc.contributor.author Liu, John (John Hsiao-Yung) en_US
dc.contributor.other Massachusetts Institute of Technology. Dept. of Mechanical Engineering. en_US
dc.date.accessioned 2012-11-19T19:33:16Z
dc.date.available 2012-11-19T19:33:16Z
dc.date.copyright 2012 en_US
dc.date.issued 2012 en_US
dc.identifier.uri http://hdl.handle.net/1721.1/74993
dc.description Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2012. en_US
dc.description Cataloged from PDF version of thesis. en_US
dc.description Includes bibliographical references (p. 65-67). en_US
dc.description.abstract This thesis presents a new method for needle-free powdered drug injection. The design, construction, and testing of a bench-top helium-powered device capable of delivering powder to controllable depths within the dermis is presented. This device uses a jet of gas undergoing choked flow to entrain powder and subsequently penetrates through the skin for delivery of the powder. Different nozzle designs and orifice geometries are also explored. In vitro injection of polymer beads (1-5 [mu]im in diameter) into porcine tissue demonstrate the device's capability of drug delivery to depths of 260 to 5000 [mu]m. The jet parameters of nozzle orifice diameter and applied pressure are shown to affect injection depth, shape, and success rate. The presented device has the potential to be implemented with stabilized formulations of vaccines to address the cold chain problem-the cost and risk of transporting temperature sensitive vaccines to developing countries. en_US
dc.description.statementofresponsibility by John Liu. en_US
dc.format.extent 80 p. en_US
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.rights.uri http://dspace.mit.edu/handle/1721.1/7582 en_US
dc.subject Mechanical Engineering. en_US
dc.title Intradermal needle-free powdered drug injection en_US
dc.type Thesis en_US
dc.description.degree S.M. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Mechanical Engineering. en_US
dc.identifier.oclc 815749543 en_US


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