Browsing MIT Libraries by Title
Now showing items 19315-19334 of 61744
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Engineered synthetic translational control for next generation mRNA gene therapies
(Massachusetts Institute of Technology, 2019)Synthetic mRNA is an emerging therapeutic modality for gene and cell therapy. Unlike their synthetic DNA counterparts, synthetic mRNA has an increased safety profile due to its transient gene expression and ability to ... -
Engineered tools for studying the malaria parasite plasmodium falciparum
(Massachusetts Institute of Technology, 2015)New techniques to both prevent and treat the disease malaria are necessary. To develop these novel strategies, innovative tools must be designed to study the basic biology within Plasmodium falciparum and characteristics ... -
Engineered, functional, human microvasculature in a perfusable fluidic device
(Massachusetts Institute of Technology, 2017)Engineered, human tissue models will enable us to study disease more accurately, and develop treatments more economically, than ever before. Functional tissue grown in the laboratory will also provide a much-needed source ... -
Engineered, perfusable, human microvascular networks on a microfluidic chip
(Massachusetts Institute of Technology, 2013)In this thesis, we developed a reliable platform for engineering perfusable, microvascular networks on-demand using state of the art microfluidics technology. We have demonstrated the utility of this platform for studying ... -
Engineering a campus-wide accessible music library
(Massachusetts Institute of Technology, 2005)The Library Access to Music Project has created a new kind of music library at the Massachusetts Institute of Technology. The library is always open and available in dormitory rooms and classrooms, because it transmits ... -
Engineering a comet-based platform for specific, sensitive, and high throughput assessment of multiple DNA repair pathways in humans
(Massachusetts Institute of Technology, 2015)Human exposure to dangerous genotoxins is unavoidable, as DNA damaging agents are ubiquitous both in our environment and within our cells. The diversity in lesions induced by these agents led to the evolution of several ... -
Engineering a culture that promotes innovation
(Massachusetts Institute of Technology, 2018)In today's world, innovation has become a well-worn, sometimes over-used buzzword. Much of today's innovation is mainly linked with new technologies. Many companies talk about innovation using new metrics like "innovation ... -
Engineering a global resolution service
(Massachusetts Institute of Technology, 1997) -
Engineering a highly enantioselective horseradish peroxidase by directed evolution
(Massachusetts Institute of Technology, 2009)There is an ever-growing demand for enantiopure chemical compounds, particularly new pharmaceuticals. Enzymes, as natural biocatalysts, possess many appealing properties as robust asymmetric catalysts for synthetic chemistry. ... -
Engineering a human Factors analysis of a novel one Atmosphere Diving Suit (ADS) elbow joint
(Massachusetts Institute of Technology, 2018)An Atmospheric Diving Suit (ADS) is a one person anthropomorphic submersible which is used to facilitate undersea work while keeping the diver/operator at atmospheric pressure thus removing them from the harmful physiological ... -
Engineering a novel pathway for isoprenoid synthesis
(Massachusetts Institute of Technology, 2019)Isoprenoids comprise a large class of chemicals, of significant interest due to their diverse properties. Most isoprenoids are plant secondary metabolites and are of commercial importance due to their varied applications ... -
Engineering a robotic exoskeleton for space suit simulation
(Massachusetts Institute of Technology, 2013)Novel methods for assessing space suit designs and human performance capabilities are needed as NASA prepares for manned missions beyond low Earth orbit. Current human performance tests and training are conducted in space ... -
Engineering a single cell microarray platform for high throughput DNA damage and repair analysis
(Massachusetts Institute of Technology, 2012)DNA damage contributes to cancer, aging, and heritable diseases. Ironically, DNA damaging agents are also commonly used in current cancer treatment. We therefore need robust, high throughput, and inexpensive tools for ... -
Engineering aglycosylated antibody variants with immune effector functions
(Massachusetts Institute of Technology, 2009)Monoclonal antibodies have emerged as a promising class of therapeutics for the treatment of human disease, and in particular human cancer. While multiple mechanisms contribute to antibody efficacy, the engagement and ... -
An engineering analysis of natural and biomimetic self-repair processes for solar energy harvesting
(Massachusetts Institute of Technology, 2012)Plants have evolved highly sophisticated mechanisms of self-repair to regenerate proteins that become photo-damaged over time. Key to this self-repair process is the reversible self-assembly of protein complexes, which is ... -
Engineering and economic implications of ice-classed containerships
(Massachusetts Institute of Technology, 2009)The Arctic is becoming increasingly attractive for shipping. With the potential savings in transit time and the untapped natural resources, both the shipping and offshore industries are pouring capital into research and ... -
Engineering and environmental problems in reservoirs constructed in karst terrain case study : the Three Gorges Dam, China
(Massachusetts Institute of Technology, 2001) -
Engineering and policy analysis of strategic and tactical options for future aerospace traffic management
(Massachusetts Institute of Technology, 2002)Current space launch/landing events are conducted only within Special Use Airspace (SUA), separate from air traffic. This is a strategic traffic management policy because SUA size and duration are set well in advance. It ... -
Engineering and targeting glycan receptor binding of influenza A virus hemagglutinin
(Massachusetts Institute of Technology, 2011)The critical first step in the host infection by influenza A virus is the binding of the viral surface glycoprotein hemagglutinin (HA) to the sialylated glycan receptors terminated by N-acetyineuraminic acid (Neu5Ac) ... -
Engineering antibodies for improved targeting of solid tumors
(Massachusetts Institute of Technology, 2010)Monoclonal antibodies have emerged as an important class of cancer therapeutics due to their ability to specifically bind tumor-expressed antigens. Unfortunately, attempts to treat solid tumors with these drugs are often ...
