Browsing MIT Libraries by Title
Now showing items 45596-45615 of 61744
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Protein design with hierarchical treatment of solvation and electrostatics
(Massachusetts Institute of Technology, 2002)A detailed treatment of the electrostatic energy of biomolecules in solution is used for two applications that require consideration of large numbers of states: multiple-site titration and protein design. The continuum ... -
Protein dissection of the Ebola virus glycoprotein
(Massachusetts Institute of Technology, 1998) -
Protein engineering and bioprospecting for selective hydroxyacid production in engineered Escherichia coli
(Massachusetts Institute of Technology, 2016)Engineering of microbes can allow for the sustainable production of a variety of useful chemical compounds upon which we rely in our everyday lives. The many advantages of metabolic engineering include the use of renewable ... -
Protein engineering and pattern recognition
(Massachusetts Institute of Technology, 1994) -
Protein engineering design principles for the development of biosensors
(Massachusetts Institute of Technology, 2015)Investigating protein location and concentration is critical to understanding function. Reagentless biosensors, in which a reporting fluorophore is conjugated to a binding scaffold, can detect analytes of interest with ... -
Protein engineering for cancer therapy
(Massachusetts Institute of Technology, 2012)The immunosuppressive effects of CD4⁺CD25⁺ regulatory T cells (Tregs) interfere with anti-tumor immune responses in cancer patients. In the first part of this work, we present a novel class of engineered Interleukin-2 ... -
Protein engineering for targeted delivery of radionuclides to tumors
(Massachusetts Institute of Technology, 2010)Traditional cancer treatment strategies include systemic chemotherapy, external beam radiation, and surgical excision. Chemotherapy is nonspecific, and targets all rapidly dividing cells. External beam radiation and surgery ... -
Protein engineering of Heparinase I : elucidation of structure-activity relationships
(Massachusetts Institute of Technology, 1996) -
Protein engineering of targeted cancer therapies
(Massachusetts Institute of Technology, 2017)Protective antigen (PA). the pore-forming component of anthrax toxin, has emerged as a platform for the development of cancer therapies because of its versatility and robust ability to translocate proteins into a cell's ... -
Protein expression and glycosylation in CHO cells
(Massachusetts Institute of Technology, 2001)A successful mammalian cell culture process depends on sufficient expression and correct glycosylation of the recombinant product. Low product titer and inconsistent protein glycosylation constitute two major problems ... -
Protein immobilization using complex coacervates and complex coacervate thin films
(Massachusetts Institute of Technology, 2021)Enzymes can enable a wide and growing range of chemistries, often outperforming synthetic catalysts. However, enzymes must often be converted to heterogeneous catalysts. Protein immobilization enables this conversion and ... -
Protein localization during the cyanobacterial circadian cycle
(Massachusetts Institute of Technology, 2008)Circadian clocks are ubiquitous throughout the living world. Of these circadian clocks, the simplest one is found in cyanobacteria - unicellular, photosynthetic marine organisms. Studies of the circadian clock of Synechococcus ... -
Protein MAS NMR methodology and structural analysis of protein assemblies
(Massachusetts Institute of Technology, 2010)Methodological developments and applications of solid-state magic-angle spinning nuclear magnetic resonance (MAS NMR) spectroscopy, with particular emphasis on the analysis of protein structure, are described in this thesis. ... -
Protein mimetic nanoparticles
(Massachusetts Institute of Technology, 2019)Gold nanoparticles with amphiphilic surface functionalization have been shown to spontaneously fuse with lipid bilayers through a non-endocytic mechanism that generates minimal membrane perturbation. The membrane translocation ... -
Protein potentials and domains : re-use and composability
(Massachusetts Institute of Technology, 2017)Protein-protein interactions are one of the cornerstones of biological processes throughout the cell. Unfortunately, lack of available data precludes many possible approaches to modeling these fundamental interactions at ... -
Protein quality control in the mammalian endoplasmic reticulum
(Massachusetts Institute of Technology, 2011)Quality control is an important part of protein biogenesis. Aberrant proteins must be destroyed before they aggregate and cause deleterious effects. Failure to do so can result in cell death or malfunction and, ultimately, ... -
Protein quality control processes in the yeast golgi
(Massachusetts Institute of Technology, 1997) -
Protein regulation in Trichodesmium and other marine bacteria : observational and interpretive biomarkers of biogeochemical processes
(Massachusetts Institute of Technology, 2020)Marine microbes play key roles in global biogeochemistry by mediating chemical transformations and linking nutrient cycles to one another. A major goal in oceanography is to predict the activity of marine microbes across ... -
Protein secondary structure mimetics : design, synthesis and evaluation
(Massachusetts Institute of Technology, 1996) -
Protein sequencing using a combination of mass spectrometric methods
(Massachusetts Institute of Technology, 1996)
