Browsing MIT Libraries by Title
Now showing items 45951-45970 of 61663
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Quantitative analysis and modeling of microembolic phenomena
(Massachusetts Institute of Technology, 2006)This thesis explores parameters that govern microvascular occlusion secondary to embolic phenomenon. Bulk and individual properties of microembolic particles were characterized using light microscopy, SEM and optically-based ... -
Quantitative analysis and modulation of the spatial operation of the EGF receptor autocrine cell signaling system
(Massachusetts Institute of Technology, 2001)The spatial localization of EGFR autocrine systems is a critical factor for tissue development and homeostasis. It is difficult to analyze these systems, however, because they are both self-contained and recursive. To ... -
Quantitative analysis of 200 meter track times
(Massachusetts Institute of Technology, 2017)Using male, varsity, division 3 collegiate track and field results from the past decade, critical coaching decisions such as optimizing meet scheduling, targeting efficient training programs to mimic, and identifying ... -
Quantitative analysis of 2D and 3D models for epidermal growth factor receptor-dependent cell migration in the context of the extracellular microenvironment
(Massachusetts Institute of Technology, 2009)Major therapeutic efforts have been devoted to targeting the epidermal growth factor receptor (EGFR), which is aberrantly expressed in many cancers and is correlated with tumor progression and invasiveness. In the current ... -
Quantitative analysis of adenoviral vector modification of a cytokine-mediated cell death decision
(Massachusetts Institute of Technology, 2006)Intracellular networks arise from complex interactions between proteins that relay signals and control cellular responses. Viruses, with limited genetic material, can modify network signals and change cell behavior. ... -
Quantitative analysis of alternative transportation under environmental constraints
(Massachusetts Institute of Technology, 2006)This thesis focuses on the transportation sector and its role in emissions of carbon dioxide (CO2) and conventional pollutant emissions. Specifically, it analyzes the potential for hydrogen based transportation, introducing ... -
Quantitative analysis of anisotropic edge retraction during solid-state dewetting of thin single crystal films
(Massachusetts Institute of Technology, 2012)In the as-deposited state, thin films are generally far from equilibrium and will agglomerate or dewet to form arrays of islands when sufficient atomic motion is allowed. Dewetting can occur well below the films' melting ... -
Quantitative analysis of apoptotic decisions in single cells and cell populations
(Massachusetts Institute of Technology, 2007)Apoptosis is a form of programmed cell death that is essential for the elimination of damaged or unneeded cells in multicellular organisms. Inactivation of apoptotic cell death is a necessary step in the development of ... -
Quantitative analysis of axon elongation : a novel application of stochastic modeling techniques to long-term, high-resolution time-lapse microscopy of cortical axons
(Massachusetts Institute of Technology, 2010)Axons exhibit a rich variety of behaviors, such as elongation, turning, branching, and fasciculation, all in service of the complex goal of wiring up the brain. In order to quantify these behaviors, I have developed a ... -
Quantitative analysis of carbon fluxes for fat biosynthesis in wild-type and IRS-1 knockout brown adipocytes
(Massachusetts Institute of Technology, 2005)Excessive fat synthesis and the subsequent dysregulation of lipid metabolism constitute the major pathological factors of obesity and type 2 diabetes through triggering insulin resistance. Thus, controlling fat synthesis ... -
Quantitative analysis of cell decision processes in response to inflammatory cues and their role in mediating genotoxicity in hepatocytes
(Massachusetts Institute of Technology, 2012)While a link between chronic inflammation and cancer has been established, the mechanisms of genotoxicity in inflammatory environments remain poorly understood. We hypothesized that inflammation may provide cues that allow ... -
Quantitative analysis of cellular processing of Antibody-Drug Conjugates
(Massachusetts Institute of Technology, 2016)Antibody-Drug Conjugates (ADCs) are a promising therapeutic class which combines the potency of chemotherapeutic drugs with the specificity of a tumor targeting antibody. ADCs aim to reduce systemic toxicity and maintain ... -
Quantitative analysis of cerebral white matter anatomy from diffusion MRI
(Massachusetts Institute of Technology, 2008)In this thesis we develop algorithms for quantitative analysis of white matter fiber tracts from diffusion MRI. The presented methods enable us to look at the variation of a diffusion measure along a fiber tract in a single ... -
A quantitative analysis of chemotherapy-induced reactive oxidative species using genetically encoded sensors and generators
(Massachusetts Institute of Technology, 2015)Recent advances in chemotherapeutic development have targeted vital mechanisms that ensure survival of cancer cells; these include the ability to evade immune surveillance, undergo metabolic adaptations and form a defense ... -
Quantitative analysis of cytokine-induced hepatocellular death in the context of hepatotoxic therapeutics
(Massachusetts Institute of Technology, 2009)Numerous therapeutics, such as viral gene therapy vectors, have unintended toxicity in part due to interactions with inflammatory cytokine signaling to elicit hepatocyte death, thus limiting their clinical use. Although ... -
Quantitative analysis of earth resistivity data
(Massachusetts Institute of Technology, 1956) -
Quantitative analysis of ice accretion roughness using spectral and stochastic techniques
(Massachusetts Institute of Technology, 1996) -
Quantitative analysis of IL-2 and IL-15 signal transduction in T lymphocytes
(Massachusetts Institute of Technology, 2013)IL-2 and IL-15 are common y-chain family cytokines critically involved in regulation of T cell differentiation and homeostasis. Both cytokines signal through a heterotrimeric surface receptor complex (IL-2/15R) composed ... -
Quantitative analysis of intro-operative magnetic resonance images and tissue survival for laserthermia of 9L gliosarcoma
(Massachusetts Institute of Technology, 1994) -
Quantitative analysis of non-viral gene therapy in primary liver culture systems
(Massachusetts Institute of Technology, 2007)Gene therapy has the potential to cure thousands of diseases caused by genetic abnormalities, provide novel combination therapies for cancers and viral infections, and offer a new and effective platform for next generation ...
