Search
Now showing items 11-20 of 80
Optimal handling of Highly Active Pharmaceutical Ingredients during milling and blending operations
(Massachusetts Institute of Technology, 2013)
This thesis investigates best practices for Highly Active Pharmaceutical Ingredient (HAPI) milling and blending. We utilize a qualitative analysis centering on a benchmarking study and quantitative analyses using a ...
Analyzing and improving throughput of Automated Storage and Retrieval Systems in personal computer manufacturing
(Massachusetts Institute of Technology, 2005)
The content of this thesis draws heavily on work completed during a 6.5 month MIT Leaders for Manufacturing (LFM) internship at Dell Corporation's personal computer manufacturing facility in Lebanon, Tennessee (EG1) from ...
Bioreactor Fill Process Control Using Inline Concentration Measurement
(Massachusetts Institute of Technology, 2014)
Some biopharmaceutical companies have responded to evolution of the competitive landscape by placing additional emphasis on reducing their costs of manufacturing as a means of maintaining competitiveness. The prototypical ...
Information management using Web 2.0 technology
(Massachusetts Institute of Technology, 2009)
Web 2.0, the ultimate platform for tacit based knowledge work has finally arrived. User driven, collaborative platform based tools including wikis, web mash-ups, discussion boards, linkage based search engines, and tagging ...
Forecasting resource requirements for drug development long range planning
(Massachusetts Institute of Technology, 2010)
This thesis investigates the use of a task-based Monte Carlo simulation model to forecast headcount and manufacturing capacity requirements for a drug development organization. A pharmaceutical drug development group is ...
Fuel cells : manufacturing strategy for emerging technologies
(Massachusetts Institute of Technology, 2001)
Firms attempting to commercialize emerging technologies face unique challenges. Strategy making is one of the major challenges especially when the industry structure is embryonic. In this environment, it is important not ...
Achieving business and operational excellence in the pharmaceutical industry
(Massachusetts Institute of Technology, 2008)
Historically the pharmaceutical industry has been highly profitable. However, the increasing regulatory requirements, bargaining power of buyers, and drug failures together with the threat of biosimilars and decreasing R&D ...
Reducing complexity In biomanufacturing operations through single-use assemblies
(Massachusetts Institute of Technology, 2012)
Novartis Vaccines and Diagnostics operates a centralized equipment cleaning and preparation suite at a vaccine production facility in Marburg, Germany. The ~100 pieces of multi-use stainless steel, glass, and plastic ...
Operational streamlining in a high-throughput genome sequencing center
(Massachusetts Institute of Technology, 2006)
Advances in medicine rely on accurate data that is rapidly provided. It is therefore critical for the Genome Sequencing platform of the Broad Institute of MIT and Harvard to continually strive to reduce cost, improve ...
Evaluating a continuous improvement initiative using Stakeholder Value Mapping
(Massachusetts Institute of Technology, 2006)
Lean implementations have had a mixed record of success in organizations. One possible explanation for this observation is that lean is built upon a value system that is not always shared by the organizations trying to ...