Browsing Biology - Ph.D. / Sc.D. by Title
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Browsing Biology - Ph.D. / Sc.D. by Title
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(Massachusetts Institute of Technology, 2003)Many organisms, in response to selective pressures imposed by their environment, have evolved mechanisms that allow them to generate phenotypic variation. Such phenotypic variation can result from genetic regulation, in ...
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(Massachusetts Institute of Technology, 2007)In order to study a complex biological phenomenon such as tumor cell metastasis, one must focus on examining discrete aspects of the process which are amenable to experimentation. In this thesis, I made use of xenograft ...
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 1998)
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(Massachusetts Institute of Technology, 1993)
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(Massachusetts Institute of Technology, 1994)
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 1994)
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(Massachusetts Institute of Technology, 2003)The E2F transcription factors are critical downstream targets of the retinoblastoma protein (pRB) pathway. A component of the pRB pathway is mutated in most human tumors resulting in deregulation of cell cycle control ...
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(Massachusetts Institute of Technology, 1998)
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 2006)Coronary heart disease (CHD) is a major healthcare concern in both developed and developing nations. The principal cause of CHD is atherosclerosis, the buildup of fatty deposits in vessel walls. SR-BI/apoE double knockout ...
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(Massachusetts Institute of Technology, 2003)Cytosine-5-methylation has been associated with repression of transcription across eukaryotic phyla. In mammals, defects in methylation are associated with disease, developmental defects, and lethality. Furthermore, ...
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(Massachusetts Institute of Technology, 1998)
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(Massachusetts Institute of Technology, 2011)When different cells thrive across diverse environments, their genetic differences can reveal what genes are essential to survival in a particular environment. Prochlorococcus, a cyanobacterium that dominates the open ...
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(Massachusetts Institute of Technology, 1977)
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 2007)Dietary restriction (DR), the limitation of food intake below the ad libidum (AL) level without malnutrition, extends mean and maximum lifespan in every organism in which it has been tested. Perhaps even more significantly, ...
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(Massachusetts Institute of Technology, 1987)
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(Massachusetts Institute of Technology, 2009)The cells of metazoan organisms possess the capability to commit a form of cellular suicide known as programmed cell death or apoptosis. The proper control of this endogenous death program is essential to animal development ...
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