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Browsing Biology - Ph.D. / Sc.D. by Title

Research and Teaching Output of the MIT Community

Browsing Biology - Ph.D. / Sc.D. by Title

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  • Lowery, Laura Anne (Massachusetts Institute of Technology, 2008)
    The brain ventricles are a conserved system of fluid-filled cavities within the brain that form during the earliest stages of brain development. Abnormal brain ventricle development has been correlated with neurodevelopmental ...
  • Torres-Delgado, Amaris (Massachusetts Institute of Technology, 2016)
    The proteome of a cell needs to be constantly modified for protein quality control and to respond to environmental and developmental changes. Energy-dependent proteases are key to ensuring the proper composition of the ...
  • Bent, Eric Huttenlocher (Massachusetts Institute of Technology, 2016)
    Chemoresistance remains a major barrier to the effective treatment of cancer. Cancer therapy occurs in the context of a tissue environment, with cancer cells surrounded by many non-malignant cells that contribute to tumor ...
  • Vasquez, Claudia G. (Claudia Gabriela) (Massachusetts Institute of Technology, 2015)
    Throughout organismal development, precise three-dimensional organization of tissues is required for proper tissue function. These three-dimensional forms are generated by coordinated cell shape changes that induce global ...
  • Chan, Leon Y. (Leon Yen-Lee) (Massachusetts Institute of Technology, 2010)
    Most cells are polarized in that they are aware of spatial cues and can respond to these cues accordingly. One major aspect of cell function that is often responsive to these polarization cues is cell division. Cell division, ...
  • Sundar, Shankar (Massachusetts Institute of Technology, 2011)
    Protein degradation is a central component of all biological processes. The proteome must constantly change in response to environmental stimuli. As a result, protein synthesis and regulated proteolysis are vital to cell ...
  • Tanny, Robyn E (Massachusetts Institute of Technology, 2006)
    Every time a cell divides it must faithfully duplicate its genome before the cell divides. If replication initiates a second time (re-replication) before cytokinesis, cells can accumulate extensive DNA damage, which results ...
  • Bumgarner, Stacie L (Massachusetts Institute of Technology, 2008)
    The FLO promoters are among the largest promoters in yeast and receive a complex combination of signals from upstream signaling pathways through their association with downstream DNA binding factors and chromatin remodelers. ...
  • Piccioli, Zachary D. (Zachary David) (Massachusetts Institute of Technology, 2014)
    The Drosophila neuromuscular junction (NMJ) is capable of rapidly budding new presynaptic varicosities over the course of minutes in response to elevated neuronal activity. Using live imaging of synaptic growth, we ...
  • Falk, Jill E (Massachusetts Institute of Technology, 2016)
    During mitosis, cells must accurately segregate their genome in order to produce healthy daughter cells. In budding yeast, cells align their anaphase spindle along a predetermined axis of division in order to partition ...
  • Nager, Andrew R. (Andrew Ross) (Massachusetts Institute of Technology, 2013)
    AAA+ proteases are present in all branches of life and responsible for the energy-dependent degradation of most cytosolic proteins. Substrates for AAA+ proteases are unfolded and translocated into a compartmental peptidase. ...
  • Whitfield, Zachary James (Massachusetts Institute of Technology, 2013)
    Cell cycle transitions during mitosis and meiosis must proceed in an irreversible manner. At the heart of this is the Anaphase Promoting Complex/Cyclosome (APC/C), an E3 ubiquitin ligase. The APC/C targets its substrates ...
  • Page, Andrea Wilder (Massachusetts Institute of Technology, 1998)
  • Miller, Matthew P., Ph. D. (Matthew Paul). Massachusetts Institute of Technology (Massachusetts Institute of Technology, 2013)
    During meiosis, a single round of DNA replication is followed by two consecutive rounds of nuclear divisions called meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate, while sister chromatids remain ...
  • Mondal, Chandrani (Massachusetts Institute of Technology, 2016)
    EnaNASP proteins are a conserved family of actin regulatory proteins that modulate cell motility and morphology by altering actin dynamics. Mena, an EnaNASP protein, is alternatively spliced, producing protein isoforms ...
  • Strasser, Carly Ann (Massachusetts Institute of Technology, 2008)
    In this dissertation, I explored metapopulation dynamics and population connectivity, with a focus on the softshell clam, Mya arenaria. I first worked towards developing a method for using elemental signatures retained in ...
  • Becker, Jamie William (Massachusetts Institute of Technology, 2013)
    Marine phytoplankton are the principal producers of oceanic dissolved organic matter (DOM), the organic substrate responsible for secondary production by heterotrophic microbes in the sea. Despite the importance of DOM in ...
  • Melom, Jan E. (Jan Elizabeth) (Massachusetts Institute of Technology, 2013)
    Glial cells exhibit spontaneous and activity-dependent fluctuations in intracellular Ca²+, yet it is unclear whether glial Ca²+ oscillations are required during neuronal signaling. Somatic glial Ca²+ waves are primarily ...
  • Weinstein, Earl G., 1974- (Massachusetts Institute of Technology, 2002)
    Part I. Two gene-regulatory noncoding RNAs (ncRNAs), let-7 RNA and lin-4 RNA, were previously discovered in the C. elegans genome. The let-7 gene is conserved across a wide range of genomes, suggesting that these ncRNAs ...
  • Kumar, Madhu S. (Madhu Sudham) (Massachusetts Institute of Technology, 2009)
    MicroRNAs (miRNAs) are a novel class of small (approximately 23 nucleotides long), highly conserved, non-coding RNAs that function by broadly regulating gene expression. In animals, this regulation is achieved via interaction ...
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