Homeostatic forms of plasticity keep the spiking output of neurons within an optimal range in the face of changing activity levels of the surrounding network, but little is known about the underlying molecular mechanisms, ...

Germ cells are the only cell type to undergo meiosis, a specialized cell division process necessary for the formation of haploid gametes. Timing of this process is sex-specific. Ovarian germ cells initiate meiosis during ...

Spermatogenesis is a highly regulated, cyclical process where sperm are constantly produced. Previous work characterizing male rodents maintained on a Vitamin A Deficient diet has demonstrated that retinoic acid (RA) governs ...

The role of Xist RNA in silencing the inactive X of female somatic cells was investigated by generating a conditional allele of the Xist gene. A system was set up in which reactivation of two X-linked genes, the endogenous ...

Mammalian development involves the process by which a single fertilized egg develops into an adult with over 200 specialized cell types, each with a distinct gene expression pattern controlling its cellular state. As cells ...

Cabinl binds calcineurin and myocyte enhancer factor 2 (MEF2) through the C-terminal region. In cell lines, these interactions inhibit calcineurin activity following TCR signaling and transcriptional activation of Nur77 ...