The experiments presented in this thesis use mutation analysis, and study of the cells of mice with a deletion allele for the Trp53 gene, to explore both the regulation of p53, and its downstream functions mediated by ...

Primary producers play a critical role in the oceanic food chain and the global cycling of carbon. The marine diazotroph Trichodesmium is a major contributor to both primary production and nitrogen fixation in the tropical ...

Asymmetric cell division allows for better environmental adaptation and organismal complexity. Cells often divide by binary fission to form two identical daughter cells with similar developmental fates. However, a cell can ...

pRB is a member of the pocket protein family, which includes the closely related proteins p107 and p130. The pocket proteins are critical regulators of the cell cycle and function to restrain proliferation by controlling ...

Advances in genome sequencing and comparative genomics have uncovered ancient duplications in the genomes of many extant organisms. Evidence for large regional duplications is observed in eukaryotic organisms that include ...

The product of the retinoblastoma gene, pRB, was the first known and cloned tumor suppressor gene and it is functionally inactivated in most human cancers. pRB is thought to suppresses tumorigenesis by restraining cellular ...