Browsing Biology - Ph.D. / Sc.D. by Issue Date
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Browsing Biology - Ph.D. / Sc.D. by Issue Date
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(Massachusetts Institute of Technology, 2013)Regeneration is widespread among animals, yet very little is known about the molecular mechanisms that govern regenerative processes. Planarians have emerged in recent years as a powerful model for studying regeneration ...
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(Massachusetts Institute of Technology, 2013)Oogenesis is a developmental program by which a gametogenesis-competent germ cell becomes a fertilization-competent egg. During oogenesis, growth and differentiation of oocytes are closely coordinated with initiation and ...
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(Massachusetts Institute of Technology, 2013)The sinking flux of particles is an important removal mechanism of carbon from the surface ocean as part of the biological pump and can play a role in cycling of other chemical species. This work dealt with improving methods ...
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(Massachusetts Institute of Technology, 2013)AAA+ proteases are present in all branches of life and responsible for the energy-dependent degradation of most cytosolic proteins. Substrates for AAA+ proteases are unfolded and translocated into a compartmental peptidase. ...
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(Massachusetts Institute of Technology, 2013)Seafloor digital imagery and bathymetric data are used to evaluate the volcanic characteristics of the 85°E segment of the ultraslow spreading Gakkel Ridge (9 mm yr-¹). Imagery reveals that ridges and volcanic cones in the ...
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Microdomain calcium oscillations in Drosophila glia regulate seizure susceptibility and require NCKX (Massachusetts Institute of Technology, 2013)Glial cells exhibit spontaneous and activity-dependent fluctuations in intracellular Ca²+, yet it is unclear whether glial Ca²+ oscillations are required during neuronal signaling. Somatic glial Ca²+ waves are primarily ...
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(Massachusetts Institute of Technology, 2013)During meiosis, a single round of DNA replication is followed by two consecutive rounds of nuclear divisions called meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate, while sister chromatids remain ...
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(Massachusetts Institute of Technology, 2013)Coastal and estuarine environments experience large variability and rapid shifts in pCO₂ levels. Elevated pCO², or ocean acidification, often negatively affects early life stages of calcifying marine invertebrates, including ...
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(Massachusetts Institute of Technology, 2013)Intact polar diacylglycerolipids (IP-DAGs) were used to study microbial dynamics in the surface ocean. IP-DAGs from surface ocean seawater were quantified using high performance liquid chromatography-mass spectrometry ...
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(Massachusetts Institute of Technology, 2012)The objective of this work is to obtain an in depth understanding of how embryonic stem cell-secreted signals contribute to their identity. We analyze the contribution of broad and specific signals present in the cell-secreted ...
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(Massachusetts Institute of Technology, 2012)MicroRNAs (miRNAs) are short RNAs that regulate many processes in physiology and pathology by guiding the repression of target messenger RNAs. For classification purposes, miRNAs are defined as ~22 nt RNAs that are produced ...
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(Massachusetts Institute of Technology, 2012)The internal methylation of mRNA post-transcriptionally is an essential component of the mRNA editing machinery in virtually every eukaryotic system. Despite this ubiquity, little is known about the relevance, consequences ...
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(Massachusetts Institute of Technology, 2012)Sox2 is a master regulator of two distinct cellular states, that of pluripotent embryonic stem cells (ESCs) and multipotent neural progenitor cells (NPCs), but what common or distinct roles Sox2 may play in these cell types ...
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(Massachusetts Institute of Technology, 2012)Small molecule characterization is a critical limiting step in cancer drug development. At the present time, high throughput screens of natural products and combinatorial synthesis libraries generate more pharmaceutical ...
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(Massachusetts Institute of Technology, 2012)The brain ventricular system is composed of a highly conserved set of cavities that contain cerebrospinal fluid (CSF), a protein-rich fluid essential for brain function. However, little is known about the function of ...
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(Massachusetts Institute of Technology, 2012)Regulation of genes is fundamental to all living processes and can be exerted at many sequential steps. We studied several eukaryotic gene regulatory mechanisms with an emphasis on understanding the interplay between ...
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Determining protein interaction specificity of native and designed bZIP family transcription factors (Massachusetts Institute of Technology, 2012)Protein-protein interactions are important for almost all cellular functions. Knowing which proteins interact with one another is important for understanding protein function as well as for being able to disrupt their ...
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(Massachusetts Institute of Technology, 2012)The orderly assembly of neuronal circuits is specified by developmental programs of gene expression, however, the final stage in circuit development, maturation and refinement of specific synaptic connections, is strongly ...
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(Massachusetts Institute of Technology, 2012)Proteins destined for the secretory pathway are folded, posttranslationally modified, and assembled into complexes in the endoplasmic reticulum (ER). To maintain ER proteostasis, the rate of nascent peptide influx into the ...
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Rescue of Fragile X Syndrome phenotypes in Fmr1 KO mice by the small molecule PAK inhibitor FRAX486 (Massachusetts Institute of Technology, 2012)Autism is a diverse and complex family of disorders, and its prevalence is on the rise: 1 in 110 children have autism. There is no effective treatment for the symptoms which often include language and communication deficits, ...
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