Articulation of multisyllabic speech requires a high degree of accuracy in controlling the spatial (positional) and the temporal parameters of articulatory movements. In stuttering, a disorder of speech fluency, failures ...

Targeted, especially stratified or biomarker-guided, therapies offer significant advantages over traditional oncology therapies in certain settings. Selecting patients most likely to respond to a drug increases the therapeutic ...

Obtaining accurate needle placement is of critical importance in many medical scenarios. In the setting of fine needle aspiration biopsy (FNAB), manual palpation is often the only cue for determining the optimal position ...

Few empirically-derived guidelines exist for optimizing the assessment of vocal function in children with voice disorders. The goal of this investigation was to identify a minimal set of speech tasks and associated acoustic ...

The decline in Pharmaceutical R&D productivity has been attributed to high clinical failure rates suggesting that targets, leads and clinical candidates may be of lower quality in recent years. Senior R&D management generally ...

Interviews were conducted to establish a baseline for how orphan drug forecasting is currently undertaken by financial market and industry analysts with the intention of understanding the variables typically accounted for ...

This thesis is part of a larger body of research being undertaken by Dr. Fiona Murray and colleagues examining value creation and sharing between and among the three principal players in the commercialization of academic ...

Advanced laryngeal cancer is often treated by surgical removal of the larynx (laryngectomy) thus rendering patients unable to produce normal voice and speech. Laryngectomy patients must rely on an alternative means of ...

While being able to balance is something most of us take for granted, each year approximately 400,000 Americans are diagnosed with a balance disorder. In order to prevent fall-related injuries due to postural instability, ...

For a growing number of indications, combination therapies are becoming increasingly common due in part to their superior efficacy, as compared to monotherapies. In fact, in the case of infectious diseases such as AIDS and ...