Browsing Theses - Biological Engineering by Title
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Browsing Theses - Biological Engineering by Title
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(Massachusetts Institute of Technology, 2009)Optical traps have played a central role in the exploration of biological systems through the examination of molecular motors, biopolymers, and many other interactions at the nano and micro length scales. This thesis seeks ...
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(Massachusetts Institute of Technology, 2008)One goal underlying synthetic biology is to develop standard biological parts that can be reliably assembled into devices encoding higher-order functions. Here, I developed a framework for engineering post-translational ...
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(Massachusetts Institute of Technology, 2011)Biotherapeutics have revolutionized medicine with their ability to achieve unprecedented molecular recognition and mediate complex biological responses. The intracellular delivery of biotherapeutics is an unmet scientific ...
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(Massachusetts Institute of Technology, 2008)The aim of my thesis is to help enable the engineering of biological systems that behave in a predictable manner. Well-established techniques exist to engineer systems that behave as expected. Here, I apply such techniques ...
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(Massachusetts Institute of Technology, 2014)Antibody-dependent cell-mediated cytotoxicity (ADCC) is implicated in the efficacy, to some degree, of most anti-cancer monoclonal antibodies. This interaction is mediated through Fc gamma receptor (Fc[gamma]R) binding to ...
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(Massachusetts Institute of Technology, 2007)The potential of gene therapy to treat disease and improve human health is tremendous. The failure of viral gene therapy clinical trials due to toxicity, immunogenicity, and carcinogenicity has been tragic and strongly ...
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(Massachusetts Institute of Technology, 2015)Adjuvants are immunomodulators and/or formulations/delivery vehicles which enhance immune responses to vaccines. The lack of progress in the development of an HIV humoral vaccine is due, in part, to the absence of available ...
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(Massachusetts Institute of Technology, 2003)Glycosaminoglycans (GAGs) are complex polysaccharides that reside in the extracellular matrix and on the surfaces of all cells. The same complexity that contributes to the diversity of GAG function has also hindered their ...
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 1994)
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(Massachusetts Institute of Technology, 2017)Microscopy has facilitated the discovery of many biological insights by optically magnifying small structures in cells and tissues. However, the resolution of optical microscopy is limited by the diffraction of light to ...
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(Massachusetts Institute of Technology, 2009)Mechanism-based chemical kinetic models are increasingly being used to describe biological signaling. Such models serve to encapsulate current understanding of pathways and to enable insight into complex biological processes. ...
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(Massachusetts Institute of Technology, 2008)The combination of optical tweezers and single molecule fluorescence into an instrument capable of making combined, coincident measurements adds an observable dimension that allows for the examination of the localized ...
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(Massachusetts Institute of Technology, 2006)Endothelial cells show an unexpected behavior shortly after the onset of laminar flow: their crawling speed decreases ~40% within the first 30 min, but only in a confluent monolayer of endothelial cells, not in subconfluent ...
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(Massachusetts Institute of Technology, 2007)To shed light on the cell's response to its mechanical environment, we examined cell rheology at the single cell level and quantified it with nanometer spatial and microsecond temporal resolutions over a five-decade frequency ...
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(Massachusetts Institute of Technology, 2013)Unless repaired correctly, DNA double strand breaks (DSBs) can cause the loss of millions of base pairs of information and can induce cellular toxicity. DSBs are repaired via mitotic homologous recombination (HR), ...
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(Massachusetts Institute of Technology, 2007)Cells respond to the application of force with a variety of biochemical responses modulating their shape, structure, function, and proliferation. Two force-responsive links between the inside and outside of a cell are ...
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(Massachusetts Institute of Technology, 2013)The emergent field of synthetic biology is different from many other biological engineering efforts, in that its roots, design principles, and forward engineering perspective have been adopted from electrical engineering ...
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 2004)Tissue inhibitors of metalloproteinases (TIMPs) regulate tumor growth, progression and angiogenesis in a variety of experimental cancer models and in human malignancies. However, numerous studies have revealed important ...
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