Browsing Theses - Biological Engineering by Title
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Browsing Theses - Biological Engineering by Title
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(Massachusetts Institute of Technology, 2006)Neutrophils in the pulmonary microcirculation are subjected to mechanical deformation while traveling through capillaries of sizes much smaller than the mean neutrophil diameter. This deformation has been shown to result ...
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 2006)Ex vivo expansion of hematopoietic stem cells (HSCs) is a long-standing challenge faced by both researchers and clinicians. To date, no robust, efficient method for the pure, ex vivo expansion of human HSCs has been ...
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Investigation of growth factors and cytokines that suppress adult stem cell asymmetric cell kinetics (Massachusetts Institute of Technology, 2005)Adult stem cells are potentially useful in many biomedical applications that can save lives and increase the quality of a patient's life, such as tissue engineering, cell replacement, and gene therapy. However, these ...
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(Massachusetts Institute of Technology, 1992)
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(Massachusetts Institute of Technology, 2001)Heparin-like glycosaminoglycans (HLGAGs) are complex polysaccharides found both in extracellular matrix (ECM) and at the cell surface where they, in a sequence-specific manner, bind to and regulate the biological activity ...
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(Massachusetts Institute of Technology, 2010)The inability of articular cartilage to repair itself after acute injury has been implicated in the development of osteoarthritis. The objective of this work was to develop methods for delivering growth factors to cartilage ...
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(Massachusetts Institute of Technology, 2003)Emerging medical technologies for effective and lasting repair of articular cartilage include delivery of cells or cell-seeded scaffolds to a defect site to initiate de novo tissue regeneration. Biocompatible scaffolds ...
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(Massachusetts Institute of Technology, 2010)Osteoarthritis (OA) is the most common form of joint disorder. Individuals who have sustained an acute traumatic joint injury are at greater risk for the development of OA. The mechanisms by which injury causes cartilage ...
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(Massachusetts Institute of Technology, 2010)Improved methods are needed for routine, inexpensive monitoring of biomarkers that could facilitate earlier detection and characterization of complex diseases like cancer. Development of new assay formats based on microfluidic, ...
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(Massachusetts Institute of Technology, 2009)Animal noses have evolved the ability to rapidly detect a seemingly infinite array of odors at minute concentrations. The basis of this sensitivity are the olfactory (smell) receptors - a large, highly related class of ...
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(Massachusetts Institute of Technology, 2012)Immunostimulatory therapies that activate immune response pathways are of great interest for overcoming the immunosuppression present in advanced tumors. Agonistic antibodies against the co-stimulatory receptors CD40 and ...
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(Massachusetts Institute of Technology, 2007)Mechanical forces play an important role in cell morphology, orientation, migration, adhesion and can even induce apoptosis. The eukaryotic cell is equipped with a dynamic frame, known as the cytoskeleton, that provides ...
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(Massachusetts Institute of Technology, 2006)Surface-based sensors take advantage of the natural high surface-to-volume ratios in microfluidic devices, low reagent consumption and high potential for integration in more complex micro total analysis systems (microTAS ...
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(Massachusetts Institute of Technology, 2004)Dynamic material properties of the isolated mouse tectorial membrane (TM) were quantified by applying sinusoidal shearing forces to the TM with a microfabricated probe (contact area 30 x 30 [micro]m²). Forces in the range ...
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(Massachusetts Institute of Technology, 2006)Osteoarthritis is characterized by synovial joint degeneration, and its cardinal pathological feature is degeneration and loss of the articular cartilage joint surface. While the aetiology of osteoarthritis is unknown, ...
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(Massachusetts Institute of Technology, 2006)Cells sense mechanical stimuli and respond by changing their phenotype, e.g. shape, gene expression, motility. This process, termed mechanotransduction, was investigated using computational and theoretical approaches, as ...
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(Massachusetts Institute of Technology, 2006)Alkyl-substituted anilines have been implicated as important etiological agents in human carcinogenesis. Specifically, 2,6-dimethylaniline (2,6-DMA), 3,5-dimethylaniline (3,5-DMA), and 3-ethylaniline (3EA) have been ...
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(Massachusetts Institute of Technology, 2009)One of the primary goals of cancer chemotherapy is the design of antitumor agents that achieve selective targeting of tumor cells while minimizing toxicity to normal tissues. We have synthesized a series of DNA damaging ...
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Metabolic and mechanistic exploration of a novel programmable genotoxicant against prostate cancer (Massachusetts Institute of Technology, 2009)Molecular design of novel pharmaceutical agents depends on a mechanistic paradigm. A library of compounds was designed to mimic some features of cisplatin that are believed to be in part responsible for its success as a ...
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