Browsing Theses - Biological Engineering by Title
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Browsing Theses - Biological Engineering by Title
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(Massachusetts Institute of Technology, 2012)The importance and pervasiveness of naturally occurring regulation of RNA function in biology is increasingly being recognized. A common regulatory mechanism uses inducible protein-RNA interactions to shape diverse aspects ...
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(Massachusetts Institute of Technology, 2009)Monoclonal antibodies have emerged as a promising class of therapeutics for the treatment of human disease, and in particular human cancer. While multiple mechanisms contribute to antibody efficacy, the engagement and ...
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(Massachusetts Institute of Technology, 2009)There is an ever-growing demand for enantiopure chemical compounds, particularly new pharmaceuticals. Enzymes, as natural biocatalysts, possess many appealing properties as robust asymmetric catalysts for synthetic chemistry. ...
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(Massachusetts Institute of Technology, 2011)The critical first step in the host infection by influenza A virus is the binding of the viral surface glycoprotein hemagglutinin (HA) to the sialylated glycan receptors terminated by N-acetyineuraminic acid (Neu5Ac) ...
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(Massachusetts Institute of Technology, 2010)Monoclonal antibodies have emerged as an important class of cancer therapeutics due to their ability to specifically bind tumor-expressed antigens. Unfortunately, attempts to treat solid tumors with these drugs are often ...
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(Massachusetts Institute of Technology, 2012)DNA damage contributes to cancer, aging, and heritable diseases. Ironically, DNA damaging agents are also commonly used in current cancer treatment. We therefore need robust, high throughput, and inexpensive tools for ...
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(Massachusetts Institute of Technology, 2009)Optical traps have played a central role in the exploration of biological systems through the examination of molecular motors, biopolymers, and many other interactions at the nano and micro length scales. This thesis seeks ...
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(Massachusetts Institute of Technology, 2008)One goal underlying synthetic biology is to develop standard biological parts that can be reliably assembled into devices encoding higher-order functions. Here, I developed a framework for engineering post-translational ...
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(Massachusetts Institute of Technology, 2011)Biotherapeutics have revolutionized medicine with their ability to achieve unprecedented molecular recognition and mediate complex biological responses. The intracellular delivery of biotherapeutics is an unmet scientific ...
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(Massachusetts Institute of Technology, 2008)The aim of my thesis is to help enable the engineering of biological systems that behave in a predictable manner. Well-established techniques exist to engineer systems that behave as expected. Here, I apply such techniques ...
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(Massachusetts Institute of Technology, 2007)The potential of gene therapy to treat disease and improve human health is tremendous. The failure of viral gene therapy clinical trials due to toxicity, immunogenicity, and carcinogenicity has been tragic and strongly ...
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(Massachusetts Institute of Technology, 2003)Glycosaminoglycans (GAGs) are complex polysaccharides that reside in the extracellular matrix and on the surfaces of all cells. The same complexity that contributes to the diversity of GAG function has also hindered their ...
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 1994)
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(Massachusetts Institute of Technology, 2009)Mechanism-based chemical kinetic models are increasingly being used to describe biological signaling. Such models serve to encapsulate current understanding of pathways and to enable insight into complex biological processes. ...
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(Massachusetts Institute of Technology, 2008)The combination of optical tweezers and single molecule fluorescence into an instrument capable of making combined, coincident measurements adds an observable dimension that allows for the examination of the localized ...
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(Massachusetts Institute of Technology, 2006)Endothelial cells show an unexpected behavior shortly after the onset of laminar flow: their crawling speed decreases ~40% within the first 30 min, but only in a confluent monolayer of endothelial cells, not in subconfluent ...
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(Massachusetts Institute of Technology, 2007)To shed light on the cell's response to its mechanical environment, we examined cell rheology at the single cell level and quantified it with nanometer spatial and microsecond temporal resolutions over a five-decade frequency ...
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(Massachusetts Institute of Technology, 2013)Unless repaired correctly, DNA double strand breaks (DSBs) can cause the loss of millions of base pairs of information and can induce cellular toxicity. DSBs are repaired via mitotic homologous recombination (HR), ...
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(Massachusetts Institute of Technology, 2007)Cells respond to the application of force with a variety of biochemical responses modulating their shape, structure, function, and proliferation. Two force-responsive links between the inside and outside of a cell are ...
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