Browsing Chemistry - Ph.D. / Sc.D. by Title
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Browsing Chemistry - Ph.D. / Sc.D. by Title
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 2014)The highly-modified, bacterial sugar N,N'-diacetylbacillosamine (diNAcBac) has been implicated in the pathogenicity of certain microbes through its incorporation onto various protein virulence factors. In particular, ...
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(Massachusetts Institute of Technology, 1981)
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(Massachusetts Institute of Technology, 2011)Iminoacetonitriles participate as reactive dienophiles in intramolecular Diels-Alder cycloadditions affording quinolizidines and indolizidines. The resulting a-amino nitrile cycloadducts are versatile intermediates that ...
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(Massachusetts Institute of Technology, 2005)I. Enantioselective Nickel-Catalyzed Reductive Couplings of Alkynes and Aldehydes Allylic alcohol synthesis via a nickel-catalyzed reductive coupling reaction of alkylsubstituted alkynes and aldehydes was studied for ligand ...
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(Massachusetts Institute of Technology, 2007)Chapter 1 describes the development of an asymmetric nucleophile-catalyzed [2+2] cycloaddition of ketenes with aldehydes. This is the first report of a catalytic enantioselective synthesis of trisubstituted [beta]-lactones. ...
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(Massachusetts Institute of Technology, 2004)(cont.) imine.
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(Massachusetts Institute of Technology, 2010)I. Enantioselective Total Synthesis of (-)-Acylfulvene, and (-)-Irofulven We report the enantioselective total synthesis of (-)-acylfulvene and (-)-irofulven, which features metathesis reactions for the rapid assembly of ...
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(Massachusetts Institute of Technology, 2012)I. Total Synthesis of the (-)-Agelastatin Alkaloids The pyrrole-imidazole family of marine alkaloids, derived from linear clathrodin-like precursors, constitutes a diverse array of structurally complex natural products. ...
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(Massachusetts Institute of Technology, 2011)Chapter I. Introduction to the Ladder Polyethers. We introduce the bioactivity of the ladder polyether natural products and provide an overview of the puzzle that is their biogenesis. Cascades of endo-selective epoxide ...
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(Massachusetts Institute of Technology, 2009)This thesis focuses on the energetics of !-helix formation in peptides and proteins. The [alpha]-helix is the most prevalent type of secondary structure found in proteins, and has arguably dominated our thinking about ...
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(Massachusetts Institute of Technology, 1994)
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Engineered heme peroxidases as genetically encoded probes with diverse applications in cell biology (Massachusetts Institute of Technology, 2015)Proteins perform myriad functions inside cells. In vitro studies of purified proteins yield important information about their function, but it is an important pursuit in cell biology to study proteins within the native ...
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(Massachusetts Institute of Technology, 2013)Major impediments to the full utility of current and potential drugs include issues of resistance and delivery. To address these challenges, in this thesis two directions of research were pursued: (1) the use of multivalent ...
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(Massachusetts Institute of Technology, 2012)This thesis explores the use of ensemble, free energy models in the study and design of molecular, biochemical systems. We use physics based computational models to analyze the molecular basis of binding affinity in the ...
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(Massachusetts Institute of Technology, 2013)Each eukaryotic cell is exquisitely divided into organellar compartments whose functions are uniquely defined by the set of proteins they possess. For each individual protein, precise targeting to a specific sub-cellular ...
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Enzyme engineering by directed evolution and applications in cellular imaging and proteomic mapping (Massachusetts Institute of Technology, 2016)A thorough understanding of biological systems on a molecular level requires tools to study individual protein components within the native cellular context. A wide panoply of enzyme-mediated labeling methodologies have ...
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Enzyme-mediated labeling of proteins and protein-protein interactions in vitro and in living cells (Massachusetts Institute of Technology, 2010)The E. coli biotin ligase enzyme, BirA, has been previously used by the Ting research group for site-specific labeling of peptide-tagged cell surface proteins. We sought to expand the utility of biotin ligase-mediated ...
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(Massachusetts Institute of Technology, 2016)The neuronal synapse is one of the most important cellular structures in neuroscience. It is the junction through which signaling occurs between neurons that in aggregate, mediates complex physiological brain function. At ...
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(Massachusetts Institute of Technology, 1979)
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