Browsing Chemistry - Ph.D. / Sc.D. by Title
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Browsing Chemistry - Ph.D. / Sc.D. by Title
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(Massachusetts Institute of Technology, 2009)The 11[beta] molecule comprises a ligand for the androgen receptor (AR), which is crucial to progression and survival of many prostate cancers, tethered to a DNA-damaging aniline mustard. The compound was designed to exhibit ...
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(Massachusetts Institute of Technology, 2008)Many enzymes and ion channels consist of multiple subunits and/or multiple distinct functional components. Coordinated conformational changes through allosteric interactions between subunits and/or between functional units ...
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(Massachusetts Institute of Technology, 2005)Polyhydroxyalkanoate (PHA) synthase from various bacterial organisms is able to catalyze the polymerization of (R)-hydroxyalkanoate-CoAs into high molecular weight PHAs under nutrient- limited conditions in the presence ...
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(Massachusetts Institute of Technology, 2004)Ribonucleotide reductases (RNR) catalyze the conversion of nucleoside diphosphates to deoxynucleoside diphosphates, an essential step in DNA replication and repair. The Class I enzyme from Escherichia coli is composed of ...
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(Massachusetts Institute of Technology, 1998)
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 2006)In order to examine the role of partial intercalation in double-stranded (ds) DNA cleavage mediated by a single bleomycin (BLM), a bulky group ([-cyclodextrin) was chemically attached to the polyamine tail of BLM A5 to ...
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(Massachusetts Institute of Technology, 2003)Chapter 1. Soluble Methane Monooxygenase: Activation of Dioxygen and Methane The mechanisms by which soluble methane monooxygenase uses dioxygen to convert methane selectively to methanol have come into sharp focus. Diverse ...
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(Massachusetts Institute of Technology, 2007)Time-resolved optical spectroscopy has been employed for mechanistic studies in model systems designed to undergo photo-induced proton-coupled electron transfer (PCET) and oxygen atom transfer (OAT) reactions, both of which ...
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(Massachusetts Institute of Technology, 2012)Ribonucleotide reductase (RNR) catalyzes the conversion of nucleotides to 2'- deoxynucleotides in all organisms. The class Ia RNR from Escherichia coli is active as an a2p2 complex and utilizes an unprecedented mechanism ...
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(Massachusetts Institute of Technology, 2009)ClpX is an archetypical representative of the AAA+ superfamily of enzymes that serves as the regulatory domain and motor for the ClpXP protease system. ClpX binds protein substrates via an amino acid sequence known as a ...
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(Massachusetts Institute of Technology, 2006)Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides to deoxynucleotides, providing the monomeric precursors required for DNA replication and repair. The class I RNRs are found in many bacteria, DNA ...
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(Massachusetts Institute of Technology, 2003)(cont.) The results of initial studies on the energetics of heterodimer formation using calorimetric techniques and site-directed mutagenesis are discussed in the context of the structures of Y2Y2, Y2Y4, and Y4Y4. As the ...
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(Massachusetts Institute of Technology, 2008)CIpA, a member of the Hspl00/Clp subset of the AAA+ superfamily, is an energy-dependent chaperone, disassembling and remodeling its protein substrates. CIpA also serves as the ATPase component of the ClpAP protease, where ...
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(Massachusetts Institute of Technology, 1994)
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(Massachusetts Institute of Technology, 2005)Mechanistic studies on copper and palladium-catalyzed C-N bond forming reactions are described. To understand the mechanistic details of these processes, several principles of physical organic chemistry have been employed. ...
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 2006)Chapter 1. Metal-Based Turn-On Fluorescent Probes for Sensing Nitric Oxide. Nitric oxide, a reactive free radical, regulates a variety of biological processes. The absence of tools to detect NO directly, rapidly, specifically ...
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(Massachusetts Institute of Technology, 1998)
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(Massachusetts Institute of Technology, 1996)
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