Browsing Health Sciences and Technology - Ph.D. / Sc.D. by Issue Date
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- Browsing Health Sciences and Technology - Ph.D. / Sc.D. by Issue Date
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Browsing Health Sciences and Technology - Ph.D. / Sc.D. by Issue Date
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(Massachusetts Institute of Technology, 2013)Anterior cruciate ligament (ACL) injuries affect over 200,000 Americans yearly, and many occur in young athletes. Current treatment options include tendon autografts and cadaveric allografts. However, these approaches often ...
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(Massachusetts Institute of Technology, 2013)Two different hemodynamic-based neuroimaging techniques were studied in this work. Near-Infrared Spectroscopy (NIRS) is a promising technique to measure cerebral hemodynamics in a clinical setting due to its potential for ...
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(Massachusetts Institute of Technology, 2013)Laryngeal dystonia (LD) is the focal laryngeal form of the neurological movement disorder called dystonia, a condition that often changes in severity depending on the posture assumed and on voluntary activity of the affected ...
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(Massachusetts Institute of Technology, 2013)The requirement that individual cells be able to communicate with one another over a range of length scales is a fundamental prerequisite for the evolution of multicellular organisms. Often diffusible chemical molecules ...
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(Massachusetts Institute of Technology, 2013)Cancer is responsible for over 7.6 million deaths worldwide; the majority of patients fail to respond to drugs or become resistant over time. In order to gain a better understanding of drug efficacy in patients, we developed ...
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(Massachusetts Institute of Technology, 2013)Elucidation of molecular mechanisms underlying metastasis is the final frontier in cancer biology research. Identifying individual pathways in the metastatic cascade could lead to development of metastasis-specific ...
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(Massachusetts Institute of Technology, 2013)Perceptual abnormalities such as hyperacusis and tinnitus often occur following acoustic overexposure. Although such exposure can also result in permanent threshold elevation, some individuals with noise-induced hyperacusis ...
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(Massachusetts Institute of Technology, 2013)When viewed under the microscope, biological tissues reveal an exquisite microarchitecture. These complex patterns arise during development, as cells interact with a multitude of chemical and mechanical cues in the surrounding ...
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(Massachusetts Institute of Technology, 2013)Bacterial infections continue to be a significant concern particularly in healthcare settings and in the developing world. Current challenges include the increasing spread of drug resistant (DR) organisms, the side effects ...
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(Massachusetts Institute of Technology, 2013)Chemical exchange saturation transfer (CEST) is a relatively new magnetic resonance imaging (MRI) acquisition technique that generates contrast dependent on tissue microenvironment, such as protein concentration and ...
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(Massachusetts Institute of Technology, 2013)Sepsis is a systemic inflammatory response that results the presence and persistence of microorganisms or their toxins in the bloodstream and it is diagnosed by detecting the presence of pathogens in blood. Despite ...
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(Massachusetts Institute of Technology, 2013)
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(Massachusetts Institute of Technology, 2013)Cell-based therapies, which rely on transplanted cells to restore function to damaged tissues, are currently under investigation in clinical trials. Stem and progenitor cells, including mesenchymal stem cells (MSCs), have ...
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(Massachusetts Institute of Technology, 2013)Vaccines have revolutionized medicine by increasing the life expectancy of children and substantially decreasing the morbidity of multiple infectious diseases worldwide. Over several decades, we have acquired significant ...
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(Massachusetts Institute of Technology, 2013)One in every 88 children is diagnosed with Autism Spectrum Disorders (ASDs), a set of neurodevelopmental conditions characterized by social impairments, communication deficits, and repetitive behavior. ASDs have a substantial ...
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(Massachusetts Institute of Technology, 2013)Acoustic overexposure can cause death of cochlear nerve fibers, even if elevations in cochlear sensitivity are reversible and even if there is no hair cell loss. We hypothesized that this primary neural degeneration does ...
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(Massachusetts Institute of Technology, 2013)The adaptive immune system is one of the primary mediators in almost every major human disease, including infections, cancer, autoimmunity, and inflammation-based disorders. It fundamentally functions as a molecular ...
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(Massachusetts Institute of Technology, 2013)Mucus is a biological hydrogel which lines the wet (non-keratinized) epithelia of the body. Mucus provides a gateway between the cells of the epithelium and the outside world, and is postulated to provide a selective ...
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(Massachusetts Institute of Technology, 2013)Many hearing aids introduce nonlinear compressive gain to accommodate the reduced dynamic range that often accompanies hearing loss. Unfortunately, when applied independently at either ear, this gain can introduce fluctuations ...
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(Massachusetts Institute of Technology, 2013)Spinal cord injury (SCI) is a significant health issue resulting in life-long disability and associated secondary complications, affecting approximately 300,000 individuals in the United States. Primary barriers to functional ...
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