Browsing Health Sciences and Technology - Ph.D. / Sc.D. by Issue Date
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- Browsing Health Sciences and Technology - Ph.D. / Sc.D. by Issue Date
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Browsing Health Sciences and Technology - Ph.D. / Sc.D. by Issue Date
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(Massachusetts Institute of Technology, 2014)Systemically infused mesenchymal stem cells (MSC) are being explored for their immunomodulatory therapeutic potential in multiple inflammatory pathologies. This therapeutic potential has been associated with the ability ...
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(Massachusetts Institute of Technology, 2014)Cancer is a complex disease of the genome exhibiting myriad somatic mutations, from single nucleotide changes to various chromosomal rearrangements. The technological advances of next-generation sequencing enable high-throughput ...
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(Massachusetts Institute of Technology, 2014)This work investigated the utility of reflectance (R), a measure of middle-ear mobility, in the differential diagnosis of pathologies responsible for conductive hearing loss (CHL). Current clinical practice cannot distinguish ...
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(Massachusetts Institute of Technology, 2014)Chronic liver disease affects more than 500 million people worldwide. The only therapy shown to directly prevent mortality is organ transplantation. However, there is growing discrepancy between supply and demand of ...
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(Massachusetts Institute of Technology, 2014)Aphasia is an impairment in the expression or comprehension of language that results from stroke, traumatic brain injury or progressive neurological disease. Approximately one million people in the United States suffer ...
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(Massachusetts Institute of Technology, 2014)Ovarian cancer is the fifth leading cause of cancer-related deaths in women and the deadliest gynecologic cancer. The current standard treatment for advanced ovarian cancer includes a minimally invasive cytoreduction ...
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(Massachusetts Institute of Technology, 2014)This work investigates the fundamental processes used by mammalian cells and organisms to make decisions during embryonic development. Current technologies that evaluate biological phenomenon often force a compromise between ...
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(Massachusetts Institute of Technology, 2014)Even prior to the elucidation of the structure of DNA, the theoretical foundations of population genetics had been well developed. Advances made by Sewall Wright, John B.S. Haldane, and Ronald A. Fisher form the basis with ...
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(Massachusetts Institute of Technology, 2014)The BMP signaling pathway is essential for embryonic development and the maintenance of tissue homeostasis. Dysregulated BMP signaling, both loss and gain-of-function, has been demonstrated in the pathogenesis of diseases ...
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(Massachusetts Institute of Technology, 2014)Gene therapy has been heralded as a possible approach to a variety of diseases and conditions, ranging from cancer and heart disease to blindness and neurodegenerative diseases. However, progress in gene therapy requires ...
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(Massachusetts Institute of Technology, 2014)Angiogenesis- the growth of new capillaries from existing vessels- is required for tumor growth; however, tumor vessels exhibit abnormal structure and function, which impairs the targeted delivery of anti-cancer agents. ...
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(Massachusetts Institute of Technology, 2013)Cell-based therapies, which rely on transplanted cells to restore function to damaged tissues, are currently under investigation in clinical trials. Stem and progenitor cells, including mesenchymal stem cells (MSCs), have ...
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(Massachusetts Institute of Technology, 2013)Elucidation of molecular mechanisms underlying metastasis is the final frontier in cancer biology research. Identifying individual pathways in the metastatic cascade could lead to development of metastasis-specific ...
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(Massachusetts Institute of Technology, 2013)Vaccines have revolutionized medicine by increasing the life expectancy of children and substantially decreasing the morbidity of multiple infectious diseases worldwide. Over several decades, we have acquired significant ...
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(Massachusetts Institute of Technology, 2013)
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(Massachusetts Institute of Technology, 2013)Sepsis is a systemic inflammatory response that results the presence and persistence of microorganisms or their toxins in the bloodstream and it is diagnosed by detecting the presence of pathogens in blood. Despite ...
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(Massachusetts Institute of Technology, 2013)Cancer is responsible for over 7.6 million deaths worldwide; the majority of patients fail to respond to drugs or become resistant over time. In order to gain a better understanding of drug efficacy in patients, we developed ...
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(Massachusetts Institute of Technology, 2013)Two different hemodynamic-based neuroimaging techniques were studied in this work. Near-Infrared Spectroscopy (NIRS) is a promising technique to measure cerebral hemodynamics in a clinical setting due to its potential for ...
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(Massachusetts Institute of Technology, 2013)Chemical exchange saturation transfer (CEST) is a relatively new magnetic resonance imaging (MRI) acquisition technique that generates contrast dependent on tissue microenvironment, such as protein concentration and ...
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(Massachusetts Institute of Technology, 2013)Bacterial infections continue to be a significant concern particularly in healthcare settings and in the developing world. Current challenges include the increasing spread of drug resistant (DR) organisms, the side effects ...
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