Browsing Health Sciences and Technology - Ph.D. / Sc.D. by Issue Date
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- Browsing Health Sciences and Technology - Ph.D. / Sc.D. by Issue Date
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Browsing Health Sciences and Technology - Ph.D. / Sc.D. by Issue Date
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(Massachusetts Institute of Technology, 2013)The adaptive immune system is one of the primary mediators in almost every major human disease, including infections, cancer, autoimmunity, and inflammation-based disorders. It fundamentally functions as a molecular ...
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(Massachusetts Institute of Technology, 2013)Chemical exchange saturation transfer (CEST) is a relatively new magnetic resonance imaging (MRI) acquisition technique that generates contrast dependent on tissue microenvironment, such as protein concentration and ...
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(Massachusetts Institute of Technology, 2013)Laryngeal dystonia (LD) is the focal laryngeal form of the neurological movement disorder called dystonia, a condition that often changes in severity depending on the posture assumed and on voluntary activity of the affected ...
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(Massachusetts Institute of Technology, 2013)Mucus is a biological hydrogel which lines the wet (non-keratinized) epithelia of the body. Mucus provides a gateway between the cells of the epithelium and the outside world, and is postulated to provide a selective ...
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(Massachusetts Institute of Technology, 2013)One in every 88 children is diagnosed with Autism Spectrum Disorders (ASDs), a set of neurodevelopmental conditions characterized by social impairments, communication deficits, and repetitive behavior. ASDs have a substantial ...
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(Massachusetts Institute of Technology, 2013)Acoustic overexposure can cause death of cochlear nerve fibers, even if elevations in cochlear sensitivity are reversible and even if there is no hair cell loss. We hypothesized that this primary neural degeneration does ...
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(Massachusetts Institute of Technology, 2013)Perceptual abnormalities such as hyperacusis and tinnitus often occur following acoustic overexposure. Although such exposure can also result in permanent threshold elevation, some individuals with noise-induced hyperacusis ...
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(Massachusetts Institute of Technology, 2013)When viewed under the microscope, biological tissues reveal an exquisite microarchitecture. These complex patterns arise during development, as cells interact with a multitude of chemical and mechanical cues in the surrounding ...
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(Massachusetts Institute of Technology, 2013)Bacterial infections continue to be a significant concern particularly in healthcare settings and in the developing world. Current challenges include the increasing spread of drug resistant (DR) organisms, the side effects ...
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(Massachusetts Institute of Technology, 2012)The field of medical image analysis continues to expand as magnetic resonance imaging (MRI) technology advances through increases in field strength and the development of new image acquisition and reconstruction methods. ...
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(Massachusetts Institute of Technology, 2012)Metastasis, the spread and growth of tumor cells from the primary site to distant organs, is arguably the most devastating and deadly attribute of cancer, and is ultimately responsible for 90% of cancer-related deaths. ...
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(Massachusetts Institute of Technology, 2012)In the past decade, thousands of human genomes have been catalogued, either by whole-genome sequencing or by targeted genotyping. The variability between human genomes encodes invaluable information about human traits and ...
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(Massachusetts Institute of Technology, 2012)Ambulation is a very important part of everyday life and its absence has a detrimental effect on an individual's quality of life. While much is understood about the neurobiological systems involved in locomotion through ...
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(Massachusetts Institute of Technology, 2012)The efficient isolation of specific bioparticles in lab-on-a-chip platforms is important for many applications in clinical diagnostics and biomedical research. The majority of microfluidic devices designed for specific ...
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(Massachusetts Institute of Technology, 2012)Afflicting almost 200 million worldwide, hepatitis C virus (HCV) mounts a chronic infection of liver hepatocytes that causes substantial morbidity and mortality. An understanding of host-virus interactions will drive the ...
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(Massachusetts Institute of Technology, 2012)Unlike lower vertebrates, capable of spontaneous hair cell regeneration, mammals experience permanent sensorineural hearing loss following hair cell damage. Although low levels of hair cell regeneration have been demonstrated ...
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(Massachusetts Institute of Technology, 2012)High throughput methods in molecular biology have changed the landscape of biomedical research. In particular, advances in massively parallel DNA sequencing and synthesis technologies are defining our genomes and the ...
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(Massachusetts Institute of Technology, 2012)Humans live in association with trillions of microbes and yet we know remarkably little about their symbiotic relationship. The role these microorganisms have in humans has been characterized only in the case of few bacteria ...
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(Massachusetts Institute of Technology, 2012)Adhesion-based cell capture on surfaces in microfluidic devices forms the basis of numerous biomedical diagnostics and in vitro assays. Solid surface microfluidic platforms have been widely explored for biomedical diagnostics ...
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(Massachusetts Institute of Technology, 2012)Vertebrate hair cells respond to mechanical stimuli with an inward current that is carried by extracellular cations through mechanically-gated transmembrane ion channels called transduction channels, located in the hair ...
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