Browsing Biological Engineering Division by Title
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Browsing Biological Engineering Division by Title
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(Massachusetts Institute of Technology, 2004)Anti-angiogenic therapy offers many benefits over traditional cytotoxic chemotherapy including fewer toxic side effects and the reduced development of drug resistance. Anti-angiogenics alone have not proven effective in ...
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(Massachusetts Institute of Technology, 2007)Our understanding of glycosaminoglycan (GAG) biology has been limited by a lack of sensitive and efficient analytical tools designed to deal with these complex molecules. GAGs are heterogeneous and often sulfated linear ...
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(Massachusetts Institute of Technology, 2005)(cont.) kinetic studies. Moderate increases ([approximately]30%) in nucleobase deamination products were observed in the SJL mice bearing the RcsX tumor, but the biological meaning of these increases awaits studies of DNA ...
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(Massachusetts Institute of Technology, 2011)Mammalian noses can detect and distinguish an inestimable number of odors at minute concentrations. Four classes of G protein-coupled receptors (GPCRs) are responsible for this remarkable sensitivity: olfactory receptors ...
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(Massachusetts Institute of Technology, 2006)The MilliF bioreactor offers great potential for the formation of i vivo-like liver tissue outside the body, making it a valuable tool for applications such as drug toxicity models and biosensors. Cell adhesion is an ...
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(Massachusetts Institute of Technology, 2006)Nonviral vector research and development has been stunted by a lack of knowledge and understanding of how vectors are trafficked within the cell. Research currently involves mass screenings of different combinations of ...
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(Massachusetts Institute of Technology, 2012)Tissue engineering is a potentially valuable tool for clinical treatment of diseases where host tissues or organs need to be replaced. Progression of engineering metabolically complex organs and tissues has been severely ...
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(Massachusetts Institute of Technology, 2012)Joint injuries are common and often result in damage to cartilage, which has a limited ability to repair itself. Tissue engineering is a promising approach for improving cartilage healing in which biomaterials and chemical ...
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Overcoming dendritic cell-mediated suppression of T cell responses in a prostate tumor environment (Massachusetts Institute of Technology, 2010)Prostate cancer is the most prevalent malignancy in American men, leading to significant mortality each year. This is in part due to a lack of effective treatments for advanced disease. The prostate is considered an ideal ...
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(Massachusetts Institute of Technology, 1998)
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(Massachusetts Institute of Technology, 2007)Gastric cancer is the second most common malignancy in the digestive system and the second leading cause of cancer-related death worldwide. Epidemiological data and experimental studies have identified several risk factors ...
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(Massachusetts Institute of Technology, 2009)One specific thesis of pathogenesis holds that diseases are dependent upon the complex interactions of multiple compounds and cofactors. While one agent may dominate, its powerful effects are mediated by ancillary factors ...
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(Massachusetts Institute of Technology, 2004)Adult tissue differentiation involves the generation of distinct cell types from adult stem cells (ASCs). Current understanding of tissue differentiation mechanisms is based on studies of protein and RNAs that asymmetrically ...
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(Massachusetts Institute of Technology, 2012)Proteorhodopsin (PR) phototrophy plays an important role in the marine ecosystem, harvesting energy from sunlight for a diverse community of hetertrophic organisms. The simple proteorhodopsin photosystem (PRPS) composed ...
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(Massachusetts Institute of Technology, 2004)It is a widely-held hypothesis that environmental mutagens play an essential role in human somatic and germinal cell mutagenesis. In particular, the finding of small amounts of chemical mutagens in cigarette smoke has led ...
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(Massachusetts Institute of Technology, 2006)Connective tissue progenitors (CTP) can act as a pluripotent source of reparative cells during injury and therefore have great potential in regenerative medicine and tissue engineering. However, the response of CTP to most ...
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(Massachusetts Institute of Technology, 2005)The mechanical properties of articular cartilage are associated with the extracellular matrix network of type II collagen and the proteoglycan, aggrecan, which in combination provide the tensile, shear, and compressive ...
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(Massachusetts Institute of Technology, 2009)Across numerous conventional manufacturing sites, process improvement initiatives have been shown to increase production capabilities while decreasing costs - all without a required system- wide overhaul of the manufacturing ...
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(Massachusetts Institute of Technology, 2008)Mechanical stimulation of 3-D chondrocyte cultures increases extracellular matrix (ECM) production and mechanical stiffness in regenerating cartilage. The goal of this study was to examine the progression of chondrocyte ...
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(Massachusetts Institute of Technology, 1999)
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