Browsing Biological Engineering Division by Title
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Browsing Biological Engineering Division by Title
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(Massachusetts Institute of Technology, 2005)Nitric oxide is postulated to protect cancer cells from the death-inducing effects of tumour necrosis factor alpha by S-nitrosating the active site cysteines, inhibiting cleavage of caspase-9. We aimed to test this hypothesis ...
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(Massachusetts Institute of Technology, 1994)
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(Massachusetts Institute of Technology, 2006)While many have explored how vascular processes alter gap junction communication and composition few have analyzed the role of specific gap junction connexin proteins in regulating cellular communication and wound healing. ...
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(Massachusetts Institute of Technology, 2004)(cont.) phosphoproteomics technology, IMAC/LC/MS/MS, [approximately] 200 phosphosites were identified from HT-29 cells, some of which were detected only from insulin-treated cells. Our phosphoproteomics approach also enabled ...
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(Massachusetts Institute of Technology, 2009)Cells are constantly bombarded with stimuli that they must sense, process, and interpret to make decisions. This capability is provided by interconnected signaling pathways. Many of the components and interactions within ...
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(Massachusetts Institute of Technology, 2012)Genomes experience an often hostile environment that creates a vast array of damages that can give rise to myriad biological outcomes. Fortunately, cells are equipped with networks such as direct reversal, base excision ...
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The role of base excision repair proteins in the cellular responses to the anticancer drug cisplatin (Massachusetts Institute of Technology, 2000)
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(Massachusetts Institute of Technology, 1994)
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 2006)The anticancer drug cisplatin is in widespread use but its mechanism of action is only poorly understood. Moreover, human cancers acquire resistance to the drug, which limits its clinical utility. A paradox in the field ...
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(Massachusetts Institute of Technology, 2009)Heparin-binding epidermal growth factor-like growth factor (HB-EGF) exhibits activity as a juxtacrine, paracrine, and autocrine ligand for the epidermal growth factor receptor (EGFR), and possesses the ability to bind ...
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(Massachusetts Institute of Technology, 2013)The goal of my research is to understand the mechanism by which high fat diets mediate insulin sensitivity and the role SirT3 plays in high fat diet-induced insulin resistance. Insulin resistance is defined as the inability ...
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(Massachusetts Institute of Technology, 2007)Hematopoietic stem cells (HSCs) hold great promise for the treatment of disease. The rare frequency at which HSCs occur in the bone marrow under homeostatic conditions is a limiting factor in both their study and clinical ...
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(Massachusetts Institute of Technology, 2007)A grand challenge of systems biology is to model the cell. The cell is an integrated network of cellular functions. Each cellular function, such as immune response, cell division, metabolism or apoptosis, is defined by an ...
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(Massachusetts Institute of Technology, 2008)Many cellular processes are governed by large and highly-complex networks of chemical interactions and are therefore difficult to intuit. Computational modeling provides a means of encapsulating information about these ...
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(Massachusetts Institute of Technology, 1998)
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(Massachusetts Institute of Technology, 2009)The inability of articular cartilage to heal after damage or disease has motivated investigation of novel cartilage tissue engineering technologies. The objective of this thesis was to advance the use of self-assembling ...
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(Massachusetts Institute of Technology, 2006)Molecular markers for adult stem cells (ASCs) are highly demanded for research and clinical applications. The development of specific molecular markers for ASCs has been difficult mainly due to the technical barriers in ...
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(Massachusetts Institute of Technology, 2001)Glycosaminoglycans are complex polysaccharides that exist at the cell/extracellular matrix interface. As such, these information-dense molecules are key regulators of extracellular signals. However, to date, there has been ...
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(Massachusetts Institute of Technology, 2006)Recent studies have developed preliminary wiring diagrams for a number of important biological networks. However, the design principles governing the construction and operation of these networks remain mostly unknown. To ...
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