Browsing Biological Engineering Division by Title
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Browsing Biological Engineering Division by Title
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(Massachusetts Institute of Technology, 2010)One and a half million new cancer cases are reported each year in the United States. Despite this overwhelming burden of disease, current preventative treatments and early detection techniques are inadequate. With cancers, ...
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(Massachusetts Institute of Technology, 2001)The overall aim of this project was to investigate various cellular responses and toxic effects of nitric oxide, NO' and in vitro and in vivo. Nitric oxide gives rise to a complex spectrum of reactive species in oxygenated ...
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(Massachusetts Institute of Technology, 2008)The practical viability of biomolecule-nanostructure hybrids depends critically on the functional and structural stability of biomolecules in application environments. Noncovalent interactions of biochemical functional ...
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(Massachusetts Institute of Technology, 2007)Isolated hepatocytes removed from their microenvironment soon lose their hepatospecific functions when cultured. Highly oxygen-demanding hepatocytes are commonly maintained under oxygen-deficient culture conditions, limited ...
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(Massachusetts Institute of Technology, 2006)Following exposure to DNA damage, cells initiate a stress response involving multiple protein kinase signaling cascades. The DNA damage response results in one of several possible cell-fate decisions, or cellular responses: ...
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(Massachusetts Institute of Technology, 2004)Anti-angiogenic therapy offers many benefits over traditional cytotoxic chemotherapy including fewer toxic side effects and the reduced development of drug resistance. Anti-angiogenics alone have not proven effective in ...
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(Massachusetts Institute of Technology, 2007)Our understanding of glycosaminoglycan (GAG) biology has been limited by a lack of sensitive and efficient analytical tools designed to deal with these complex molecules. GAGs are heterogeneous and often sulfated linear ...
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Nucleic acid modifications in bacterial pathogens - impact on pathogenesis, diagnosis, and therapy (Massachusetts Institute of Technology, 2014)Nucleic acids are subject to extensive chemical modification by all organisms. These modifications display incredible structural diversity, and some are essential for survival. Intriguingly, several of these modifications ...
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(Massachusetts Institute of Technology, 2005)(cont.) kinetic studies. Moderate increases ([approximately]30%) in nucleobase deamination products were observed in the SJL mice bearing the RcsX tumor, but the biological meaning of these increases awaits studies of DNA ...
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(Massachusetts Institute of Technology, 2011)Mammalian noses can detect and distinguish an inestimable number of odors at minute concentrations. Four classes of G protein-coupled receptors (GPCRs) are responsible for this remarkable sensitivity: olfactory receptors ...
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(Massachusetts Institute of Technology, 2006)The MilliF bioreactor offers great potential for the formation of i vivo-like liver tissue outside the body, making it a valuable tool for applications such as drug toxicity models and biosensors. Cell adhesion is an ...
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(Massachusetts Institute of Technology, 2006)Nonviral vector research and development has been stunted by a lack of knowledge and understanding of how vectors are trafficked within the cell. Research currently involves mass screenings of different combinations of ...
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(Massachusetts Institute of Technology, 2012)Tissue engineering is a potentially valuable tool for clinical treatment of diseases where host tissues or organs need to be replaced. Progression of engineering metabolically complex organs and tissues has been severely ...
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(Massachusetts Institute of Technology, 2012)Joint injuries are common and often result in damage to cartilage, which has a limited ability to repair itself. Tissue engineering is a promising approach for improving cartilage healing in which biomaterials and chemical ...
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Overcoming dendritic cell-mediated suppression of T cell responses in a prostate tumor environment (Massachusetts Institute of Technology, 2010)Prostate cancer is the most prevalent malignancy in American men, leading to significant mortality each year. This is in part due to a lack of effective treatments for advanced disease. The prostate is considered an ideal ...
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(Massachusetts Institute of Technology, 1998)
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(Massachusetts Institute of Technology, 2014)A major effort of systems biology is the building of accurate and detailed models of biological systems. Because biological models are large, complex, and highly nonlinear, building accurate models requires large quantities ...
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(Massachusetts Institute of Technology, 2007)Gastric cancer is the second most common malignancy in the digestive system and the second leading cause of cancer-related death worldwide. Epidemiological data and experimental studies have identified several risk factors ...
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(Massachusetts Institute of Technology, 2009)One specific thesis of pathogenesis holds that diseases are dependent upon the complex interactions of multiple compounds and cofactors. While one agent may dominate, its powerful effects are mediated by ancillary factors ...
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(Massachusetts Institute of Technology, 2004)Adult tissue differentiation involves the generation of distinct cell types from adult stem cells (ASCs). Current understanding of tissue differentiation mechanisms is based on studies of protein and RNAs that asymmetrically ...
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