Aging is a universal process that affects organisms from yeast to humans. Replicative life span in the budding yeast, Saccharomyces cerevisiae is defined as the number of daughter cells produced by a mother cell prior to ...

Neuronal communication relies on the continual replenishment of synaptic vesicles that are primed for neurotransmitter release in response to action potentials. A vast array of proteins is required to mediate synaptic ...

Precise control of cellular morphology is critical for both the development and maintenance of nervous systems. In the developing Drosophila eye, normal photoreceptor cells establish and maintain a highly polarized ...

Many organisms, in response to selective pressures imposed by their environment, have evolved mechanisms that allow them to generate phenotypic variation. Such phenotypic variation can result from genetic regulation, in ...

The E2F transcription factors are critical downstream targets of the retinoblastoma protein (pRB) pathway. A component of the pRB pathway is mutated in most human tumors resulting in deregulation of cell cycle control ...