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Browsing Department of Biology by Title
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(Massachusetts Institute of Technology, 2006)Coronary heart disease (CHD) is a major healthcare concern in both developed and developing nations. The principal cause of CHD is atherosclerosis, the buildup of fatty deposits in vessel walls. SR-BI/apoE double knockout ...
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(Massachusetts Institute of Technology, 2003)Cytosine-5-methylation has been associated with repression of transcription across eukaryotic phyla. In mammals, defects in methylation are associated with disease, developmental defects, and lethality. Furthermore, ...
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(Massachusetts Institute of Technology, 1998)
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(Massachusetts Institute of Technology, 2011)When different cells thrive across diverse environments, their genetic differences can reveal what genes are essential to survival in a particular environment. Prochlorococcus, a cyanobacterium that dominates the open ...
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(Massachusetts Institute of Technology, 1977)
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 2007)Dietary restriction (DR), the limitation of food intake below the ad libidum (AL) level without malnutrition, extends mean and maximum lifespan in every organism in which it has been tested. Perhaps even more significantly, ...
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(Massachusetts Institute of Technology, 1987)
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(Massachusetts Institute of Technology, 2009)The cells of metazoan organisms possess the capability to commit a form of cellular suicide known as programmed cell death or apoptosis. The proper control of this endogenous death program is essential to animal development ...
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 2002)Millions of single nucleotide polymorphisms (SNPs) have been identified in the human genome, and more are cataloged every day. The challenge now is to use these SNPs to discover the genetic risk factors underlying common ...
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(Massachusetts Institute of Technology, 2005)Historically, knowledge of gene-specific transcription has been accumulated by the study of the individual genetic and physical interactions between transcriptional regulators and the genes they regulate, often requiring ...
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(Massachusetts Institute of Technology, 2002)The regulation of transcription initiation is a complex phenomenon, involving DNA-binding activator and repressor proteins, histones and chromatin factors, histone-modifying enzymes, and the general transcription apparatus. ...
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(Massachusetts Institute of Technology, 2002)
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(Massachusetts Institute of Technology, 2011)In mammalian development, a single fertilized egg grows into a complex organism, comprised of organs and tissues made up of hundreds of different specialized cell types. All of these cells contain the same genome, but ...
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(Massachusetts Institute of Technology, 2006)The availability of the human and mouse genome sequences has spurred a growing interest in analyzing mouse models of human cancer using genomic techniques. Comparative genomic studies on mouse and human tumors can be ...
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(Massachusetts Institute of Technology, 2007)Small RNA-mediated gene silencing is a mechanism widely employed by eukaryotes to repress many loci including some involved in critical developmental transitions. In plants, endogenous small RNAs consist of two broad ...
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(Massachusetts Institute of Technology, 2012)In mouse, germ cells retain expression of the pluripotency markers Oct4 and Nanog longer than any other cells in the body. While somatic cells repress these markers during gastrulation, female germ cells continue to express ...
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(Massachusetts Institute of Technology, 2005)p53 is frequently altered in human tumors through missense mutations that result in accumulation of mutant p53 protein. These mutations may confer dominant-negative or gain-of- function properties to p53. To ascertain the ...
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(Massachusetts Institute of Technology, 2002)Morphogenesis is critical to the development of multicellular organisms. Morphogenesis is also a complex process that requires the coordination of many events, including cell division, cytoskeletal reorganization, cell-cell ...
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