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Browsing Department of Biology by Title
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(Massachusetts Institute of Technology, 2010)Proteolysis plays a vital role in cellular processes including regulatory pathways and protein quality control in prokaryotes and eukaryotes. ATP-dependent protein degradation is mediated by multimeric protease complexes, ...
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 1927)
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(Massachusetts Institute of Technology, 2009)Maximizing the potential of cancer immunotherapy requires model systems that closely recapitulate human disease to study T cell responses to tumor antigens and to test immune therapeutic strategies. Current model systems ...
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(Massachusetts Institute of Technology, 2011)Small cell lung cancer (SCLC) comprises 18% of all lung cancer cases and is an aggressive disease with a five-year survival rate of less than 5%, mainly due to the advanced nature of the disease at the time of diagnosis. ...
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Investigating the role of intra- and extra-cellular modulators of the transcription factor NF-kappaB (Massachusetts Institute of Technology, 2011)The nuclear factor-kappa B (NF-kappaB) family of transcription factors play a pivotal role in the inflammatory and immune responses, as well as cell growth and survival. Since its discovery 25 years ago, NF-kappaB has ...
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(Massachusetts Institute of Technology, 2012)Proteins destined for the secretory pathway are folded, posttranslationally modified, and assembled into complexes in the endoplasmic reticulum (ER). To maintain ER proteostasis, the rate of nascent peptide influx into the ...
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(Massachusetts Institute of Technology, 2010)The spindle pole body (SPB) is a large multi-protein complex that organizes microtubules in yeast. Through its function of nucleating and anchoring microtubules, the SPB is essential for cell viability. High-resolution ...
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(Massachusetts Institute of Technology, 2011)The association of tumor cells and lymphocytes has led to the hypothesis that our immune system actively inhibits the formation and progression of cancer, a phenomenon called tumor immune surveillance. T cells specific to ...
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(Massachusetts Institute of Technology, 1932)
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(Massachusetts Institute of Technology, 2003)The p53 tumor suppressor gene is thought to play a critical role in the maintenance of genetic integrity by virtue of its ability to check the growth of abnormal or damaged cells through initiation of the cell cycle arrest ...
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(Massachusetts Institute of Technology, 2002)The separation and partitioning of sister chromatids prior to cytokinesis must be tightly regulated to insure that progeny cells receive the correct number of chromosomes. The spindle assembly checkpoint prevents chromosome ...
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(Massachusetts Institute of Technology, 2004)Metastasis, or the spread of a primary tumor to distal sites in the body, is the major cause of human cancer-related morbidity and mortality. Metastasis requires a complex series of cellular events that remain poorly ...
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 2008)Protein phosphatases regulate the phosphorylation state of intracellular signaling molecules in conjunction with protein kinases. In order to better understand the role of phosphatases in the ErbB signaling network, ...
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(Massachusetts Institute of Technology, 2005)This thesis describes our characterization of a specific tetraspanin domain: the large extracellular loop (LEL). Tetraspanins are involved in cellular migration, adhesion, and metastasis, sperm-egg fusion, and viral ...
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(Massachusetts Institute of Technology, 2010)The passive chaperone a-crystallin, a small heat shock protein, is one of the ubiquitous crystallins in vertebrate lenses, along with the [beta][gamma]-crystallins. It is composed of two subunits (~ 20 kDa) aA- and ...
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 2012)shRNA screens have been very effective in identifying novel cancer genes in mammalian cells, but they have primarily been limited to in vitro applications in tumor cell lines. Whereas in vivo retroviral mutagenesis screens ...
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(Massachusetts Institute of Technology, 1998)
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