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Browsing Department of Biology by Title
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 2011)Asymmetric cell division allows for better environmental adaptation and organismal complexity. Cells often divide by binary fission to form two identical daughter cells with similar developmental fates. However, a cell can ...
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(Massachusetts Institute of Technology, 2008)In eukaryotic cells, events such as DNA replication and mitosis must be carefully coordinated in the cell cycle to ensure that the entire genome is duplicated before cells undergo cell division. In particular, initiation ...
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(Massachusetts Institute of Technology, 1978)
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(Massachusetts Institute of Technology, 2012)The endoplasmic reticulum (ER) is responsible for the folding and processing of approximately one third of proteins in eukaryotic cells, and homeostasis in this compartment is tightly regulated. The Unfolded Protein Response, ...
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 2009)pRB is a member of the pocket protein family, which includes the closely related proteins p107 and p130. The pocket proteins are critical regulators of the cell cycle and function to restrain proliferation by controlling ...
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(Massachusetts Institute of Technology, 1995)
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Polyploidy in Saccharomyces cerevisiae leads to the loss of cell cycle control in stationary phase (Massachusetts Institute of Technology, 2003)Advances in genome sequencing and comparative genomics have uncovered ancient duplications in the genomes of many extant organisms. Evidence for large regional duplications is observed in eukaryotic organisms that include ...
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 2010)RNA-binding proteins can regulate the stability, localization, and translation of their target mRNAs. Post-transcriptional regulation can orchestrate dynamic changes in gene expression, and can coordinate multiple cellular ...
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(Massachusetts Institute of Technology, 2011)The product of the retinoblastoma gene, pRB, was the first known and cloned tumor suppressor gene and it is functionally inactivated in most human cancers. pRB is thought to suppresses tumorigenesis by restraining cellular ...
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 2009)The maintenance and transmission of genetic material is critical for the survival of cells and organisms. Sexually reproducing diploid organisms undergo meiosis to produce haploid gametes, so that the resulting progeny are ...
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(Massachusetts Institute of Technology, 2008)The prion protein (PrP) is a conserved glycoprotein tethered to cell membranes by a glycosylphosphatidylinositol anchor. In mammals, PrP is expressed in many tissues, most abundantly in brain, heart, and muscle. Importantly, ...
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(Massachusetts Institute of Technology, 2005)Prochlorococcus, a unicellular cyanobacterium, is the most abundant phytoplankton in the oligotrophic, oceanic gyres where major plant nutrients such as nitrogen (N) and phosphorus (P) are at nanomolar concentrations. ...
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(Massachusetts Institute of Technology, 2008)Every cell in the human body contains the same genetic information, with few exceptions, yet each cell type enacts a distinct gene expression program to allow for highly specialized functions. These tightly controlled ...
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(Massachusetts Institute of Technology, 1979)
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(Massachusetts Institute of Technology, 2001)
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