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Browsing Department of Biology by Title
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(Massachusetts Institute of Technology, 2004)The heterodimerization of α- and β-tubulin represents a critical early step in microtubule morphogenesis. In vitro studies have defined a pathway that mediates the incorporation of monomeric tubulin polypeptides into ...
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(Massachusetts Institute of Technology, 2005)The flu is an extremely prevalent and potentially devastating disease, especially dangerous to the very young, the elderly, and to people with compromised immune systems. Influenza has a characteristic course of infection, ...
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(Massachusetts Institute of Technology, 2008)Mitotic cyclin-dependent kinases (CDKs) are best known for their essential functions in triggering entry into M-phase, where they have established roles in nuclear envelope breakdown, chromosome condensation, and Golgi ...
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(Massachusetts Institute of Technology, 2002)The process of programmed cell death is important in the development and homeostasis of multicellular organisms. The conserved morphological events of this process have been termed apoptosis. The molecular mechanisms of ...
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(Massachusetts Institute of Technology, 2011)The class A and B synthetic multivulva (synMuv) genes of C. elegans redundantly antagonize an EGF/Ras pathway to prevent ectopic vulval induction. The class B synMuv genes encode many proteins known to remodel chromatin ...
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(Massachusetts Institute of Technology, 2011)Most animals pass through a series of juvenile stages on their way from embryo to adult. These stages represent periods of time in which stage-specific developmental processes occur. At the end of development, the organism ...
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(Massachusetts Institute of Technology, 2008)In the presence of a bacterial food source, the small nematode C. elegans greatly reduces its rate of locomotion. While mechanical agitation greatly stimulates the locomotion of well-fed animals on bacteria, it does not ...
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 1998)
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(Massachusetts Institute of Technology, 2013)Sexual reproduction depends on meiosis, the specialized cell division that gives rise to gametes. During meiosis, two consecutive rounds of chromosome segregation follow one round of DNA replication to yield four haploid ...
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(Massachusetts Institute of Technology, 2004)This suggests that the S phase cyclin, which first activates DNA replication, then acts locally at the origin to prevent pre-RC formation.
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(Massachusetts Institute of Technology, 2012)The objective of this work is to obtain an in depth understanding of how embryonic stem cell-secreted signals contribute to their identity. We analyze the contribution of broad and specific signals present in the cell-secreted ...
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(Massachusetts Institute of Technology, 2012)Regeneration of missing body parts is biologically fascinating, yet poorly understood. Many instances of regeneration, such as the replacement of amphibian limbs or planarian heads, require both a source for new cellular ...
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(Massachusetts Institute of Technology, 2014)The poly(ADP-ribose) polymerase (PARP) protein family consists of seventeen enzymes and generates ADP-ribose (ADPr) posttranslational modifications onto target proteins using NAD* as a substrate. While functions for PARPs ...
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(Massachusetts Institute of Technology, 2013)Integrative and conjugative elements (ICEs) are mobile genetic elements that are normally found stably integrated into bacterial chromosomes, but under certain situations can excise and transfer to a recipient cell through ...
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 2006)Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation ...
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(Massachusetts Institute of Technology, 1994)
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(Massachusetts Institute of Technology, 2004)Bacteria keep track of their population density by using extracellular signaling molecules. In response to the accumulation of these signals, changes in gene expression coordinate the switch from unicellular activity to ...
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(Massachusetts Institute of Technology, 1987)
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