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Browsing Department of Biology by Title
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(Massachusetts Institute of Technology, 2012)The objective of this work is to obtain an in depth understanding of how embryonic stem cell-secreted signals contribute to their identity. We analyze the contribution of broad and specific signals present in the cell-secreted ...
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(Massachusetts Institute of Technology, 2012)Regeneration of missing body parts is biologically fascinating, yet poorly understood. Many instances of regeneration, such as the replacement of amphibian limbs or planarian heads, require both a source for new cellular ...
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(Massachusetts Institute of Technology, 2013)Integrative and conjugative elements (ICEs) are mobile genetic elements that are normally found stably integrated into bacterial chromosomes, but under certain situations can excise and transfer to a recipient cell through ...
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 2006)Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation ...
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(Massachusetts Institute of Technology, 1994)
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(Massachusetts Institute of Technology, 2004)Bacteria keep track of their population density by using extracellular signaling molecules. In response to the accumulation of these signals, changes in gene expression coordinate the switch from unicellular activity to ...
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(Massachusetts Institute of Technology, 1987)
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 2011)Cataract, the leading cause of blindness worldwide, is the opacification of the eye lens. In.age-related cataract, as well as roughly one half of congenital cataract cases, aggregation or precipitation of crystallin proteins ...
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 1999)
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(Massachusetts Institute of Technology, 1994)
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(Massachusetts Institute of Technology, 2001)
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(Massachusetts Institute of Technology, 2007)Conserved signal transduction pathways coordinate all aspects of metazoan development, including cell fate specification, differentiation, and growth. Rather than functioning as completely independent modules, signaling ...
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(Massachusetts Institute of Technology, 1988)
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 2003)The class A and B synthetic Multivulva (synMuv) genes function redundantly to inhibit Ras-mediated vulval development in C. elegans. The class B synMuv genes encode an Rb/DP/E2F repressor complex that likely silences genes ...
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(Massachusetts Institute of Technology, 2004)The Ets family of transcription factors is conserved throughout metazoans and plays key roles in normal development and oncogenesis. Prostate-Derived Ets Factor (PDEF), a recently identified family member in humans, is ...
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