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Browsing Department of Biology by Title
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(Massachusetts Institute of Technology, 2011)Cataract, the leading cause of blindness worldwide, is the opacification of the eye lens. In.age-related cataract, as well as roughly one half of congenital cataract cases, aggregation or precipitation of crystallin proteins ...
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 1994)
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(Massachusetts Institute of Technology, 2001)
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(Massachusetts Institute of Technology, 2007)Conserved signal transduction pathways coordinate all aspects of metazoan development, including cell fate specification, differentiation, and growth. Rather than functioning as completely independent modules, signaling ...
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(Massachusetts Institute of Technology, 1988)
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 2003)The class A and B synthetic Multivulva (synMuv) genes function redundantly to inhibit Ras-mediated vulval development in C. elegans. The class B synMuv genes encode an Rb/DP/E2F repressor complex that likely silences genes ...
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(Massachusetts Institute of Technology, 2004)The Ets family of transcription factors is conserved throughout metazoans and plays key roles in normal development and oncogenesis. Prostate-Derived Ets Factor (PDEF), a recently identified family member in humans, is ...
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(Massachusetts Institute of Technology, 2001)A gene's location in the genome can have profound effects on its ekpression. In Saccharomyces cerevisiae, the gene SIR2 is crucial for silencing at the HM mating type loci, the telomeres, and the rDNA array. It is also ...
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(Massachusetts Institute of Technology, 2005)Human [gamma]D crystallin (H[gamma]D-Crys) and human [gamma]S crystallin (H[gamma]S-Crys), are major proteins of the human eye lens and are components of cataracts. H[gamma]D-Crys is expressed early in life in the lens ...
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(Massachusetts Institute of Technology, 2001)
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(Massachusetts Institute of Technology, 2005)Regulated actin assembly drives cells movement, adhesion and shape change. The EnaNASP family of proteins controls actin filament elongation and are important regulators of axon guidance and cell motility. In vertebrates, ...
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(Massachusetts Institute of Technology, 2004)(cont.) This is consistent with an inability of dnaBS371P cells to adjust the frequency of initiation according to growth rate. I also found that cells over-producing DnaBS371P are filamentous, contain decreased DNA contents, ...
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(Massachusetts Institute of Technology, 2010)The post-translational modification of proteins is a major mechanism employed in eukaryotic cells to expand the functional diversity of the proteome. Covalent modification of amino acid side chains confers new or altered ...
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(Massachusetts Institute of Technology, 1945)
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(Massachusetts Institute of Technology, 2011)Neuroanatomical bilateral asymmetry is a widespread feature in both vertebrates and invertebrates. Although mostly bilaterally symmetric, the nervous system of Caenorhabditis elegans displays bilateral asymmetry. Bilateral ...
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(Massachusetts Institute of Technology, 1994)
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(Massachusetts Institute of Technology, 2007)The ubiquity of aneuploidy in human cancers, particularly solid tumors, suggests a fundamental link between errors in chromosome segregation and tumorigenesis. The spindle checkpoint ensures accurate chromosome segregation ...
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