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Browsing Department of Biology by Title
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(Massachusetts Institute of Technology, 2002)The essential role of classical MHC molecules in T cell development as well as the proteasome role in antigen processing for MHC-mediated antigen presentation to T cells is well established. However, the contribution of ...
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(Massachusetts Institute of Technology, 2008)The untranslated region (UTR) at the 30 end of a mammalian mRNA is typically rich with regulatory motifs that influence the stability, localization, translation and other properties of the message. We explored two classes ...
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 2008)Embryonic stem (ES) cells are of tremendous biological interest because they have the capacity, termed pluripotency, to generate any cell type of the adult organism. Our lab is interested in understanding the genetic ...
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(Massachusetts Institute of Technology, 2013)Intact polar diacylglycerolipids (IP-DAGs) were used to study microbial dynamics in the surface ocean. IP-DAGs from surface ocean seawater were quantified using high performance liquid chromatography-mass spectrometry ...
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(Massachusetts Institute of Technology, 2002)Mark-recapture analysis of populations is becoming an important tool in population biology. Mark-recapture methods can be used to estimate transition probabilities among life-stages from capture histories of marked individuals ...
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Maternal environment and offspring physiology : the inheritance of information across a generation (Massachusetts Institute of Technology, 2017)From the 4th century BC until the late 19th century AD philosophers and biologists ranging from Hippocrates to Charles Darwin hypothesized that information about the environment could be passed from parents to progeny. ...
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Measurement of in situ protein concentrations in lymphatic capillaries by ultrasoft X-ray microscopy (Massachusetts Institute of Technology, 1969)
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(Massachusetts Institute of Technology, 2003)E. coli ClpX is a member of the Clp/Hsp100 family of ATPases that remodel multi-component complexes and facilitate ATP-dependent protein degradation. Protein remodelers alter the biological activity of their substrates, ...
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(Massachusetts Institute of Technology, 2010)Bacterial two component signaling (TCS) systems are the predominant means by which bacteria sense and respond to external signals. These systems represent a large family of paralogous proteins; often hundreds of the histidine ...
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(Massachusetts Institute of Technology, 2014)Glioblastoma (GBM) is the most common and malignant form of brain cancer. After aggressive treatment, therapy resistant tumors inevitably recur. However, the molecular mechanisms underlying such resistance remain unclear. ...
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(Massachusetts Institute of Technology, 2015)AAA+ molecular machines power myriad cellular processes including protein degradation, microtubule severing, membrane fusion, and initiation of DNA replication. Protein quality control in all organisms involves deployment ...
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(Massachusetts Institute of Technology, 2016)Protein misfolding and aggregation is a ubiquitous challenge in biology and medicine. Among its many manifestations is age-onset cataract disease, the leading cause of vision loss. Cataracts arise from increased light ...
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 1981)
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(Massachusetts Institute of Technology, 2017)All life needs to replicate its genome completely and do so with limited errors. In eukaryotic cells, DNA replication is accomplished by a multi-stage process involving numerous protein assemblies. The core component of ...
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(Massachusetts Institute of Technology, 2009)Maintaining genomic integrity is crucial for an organism's fitness and survival. Regulation of chromosome segregation requires complex surveillance mechanisms that vary for different loci within the genome. This thesis ...
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(Massachusetts Institute of Technology, 2016)Each time a cell divides, the genome must be segregated equally between the two new daughter cells. To accomplish this, a specific region of each chromosome, termed the centromere, recruits the macromolecular kinetochore ...
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(Massachusetts Institute of Technology, 2018)In order to coordinate growth with organismal physiology, cells must couple anabolic and catabolic metabolism with a variety of environmental cues. In humans, cell growth is controlled primarily by the mechanistic Target ...
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(Massachusetts Institute of Technology, 2008)The brain ventricles are a conserved system of fluid-filled cavities within the brain that form during the earliest stages of brain development. Abnormal brain ventricle development has been correlated with neurodevelopmental ...
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