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Browsing Department of Biology by Title
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(Massachusetts Institute of Technology, 2002)The essential role of classical MHC molecules in T cell development as well as the proteasome role in antigen processing for MHC-mediated antigen presentation to T cells is well established. However, the contribution of ...
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(Massachusetts Institute of Technology, 2008)The untranslated region (UTR) at the 30 end of a mammalian mRNA is typically rich with regulatory motifs that influence the stability, localization, translation and other properties of the message. We explored two classes ...
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 2008)Embryonic stem (ES) cells are of tremendous biological interest because they have the capacity, termed pluripotency, to generate any cell type of the adult organism. Our lab is interested in understanding the genetic ...
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(Massachusetts Institute of Technology, 2013)Intact polar diacylglycerolipids (IP-DAGs) were used to study microbial dynamics in the surface ocean. IP-DAGs from surface ocean seawater were quantified using high performance liquid chromatography-mass spectrometry ...
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(Massachusetts Institute of Technology, 2002)Mark-recapture analysis of populations is becoming an important tool in population biology. Mark-recapture methods can be used to estimate transition probabilities among life-stages from capture histories of marked individuals ...
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Measurement of in situ protein concentrations in lymphatic capillaries by ultrasoft X-ray microscopy (Massachusetts Institute of Technology, 1969)
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(Massachusetts Institute of Technology, 2003)E. coli ClpX is a member of the Clp/Hsp100 family of ATPases that remodel multi-component complexes and facilitate ATP-dependent protein degradation. Protein remodelers alter the biological activity of their substrates, ...
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(Massachusetts Institute of Technology, 2010)Bacterial two component signaling (TCS) systems are the predominant means by which bacteria sense and respond to external signals. These systems represent a large family of paralogous proteins; often hundreds of the histidine ...
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(Massachusetts Institute of Technology, 2014)Glioblastoma (GBM) is the most common and malignant form of brain cancer. After aggressive treatment, therapy resistant tumors inevitably recur. However, the molecular mechanisms underlying such resistance remain unclear. ...
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 1981)
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(Massachusetts Institute of Technology, 2009)Maintaining genomic integrity is crucial for an organism's fitness and survival. Regulation of chromosome segregation requires complex surveillance mechanisms that vary for different loci within the genome. This thesis ...
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(Massachusetts Institute of Technology, 2008)The brain ventricles are a conserved system of fluid-filled cavities within the brain that form during the earliest stages of brain development. Abnormal brain ventricle development has been correlated with neurodevelopmental ...
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(Massachusetts Institute of Technology, 2010)Most cells are polarized in that they are aware of spatial cues and can respond to these cues accordingly. One major aspect of cell function that is often responsive to these polarization cues is cell division. Cell division, ...
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(Massachusetts Institute of Technology, 2011)Protein degradation is a central component of all biological processes. The proteome must constantly change in response to environmental stimuli. As a result, protein synthesis and regulated proteolysis are vital to cell ...
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(Massachusetts Institute of Technology, 2006)Every time a cell divides it must faithfully duplicate its genome before the cell divides. If replication initiates a second time (re-replication) before cytokinesis, cells can accumulate extensive DNA damage, which results ...
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(Massachusetts Institute of Technology, 2008)The FLO promoters are among the largest promoters in yeast and receive a complex combination of signals from upstream signaling pathways through their association with downstream DNA binding factors and chromatin remodelers. ...
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(Massachusetts Institute of Technology, 2014)The Drosophila neuromuscular junction (NMJ) is capable of rapidly budding new presynaptic varicosities over the course of minutes in response to elevated neuronal activity. Using live imaging of synaptic growth, we ...
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(Massachusetts Institute of Technology, 2013)AAA+ proteases are present in all branches of life and responsible for the energy-dependent degradation of most cytosolic proteins. Substrates for AAA+ proteases are unfolded and translocated into a compartmental peptidase. ...
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