The untranslated region (UTR) at the 30 end of a mammalian mRNA is typically rich with regulatory motifs that influence the stability, localization, translation and other properties of the message. We explored two classes ...

Embryonic stem (ES) cells are of tremendous biological interest because they have the capacity, termed pluripotency, to generate any cell type of the adult organism. Our lab is interested in understanding the genetic ...

Mark-recapture analysis of populations is becoming an important tool in population biology. Mark-recapture methods can be used to estimate transition probabilities among life-stages from capture histories of marked individuals ...

E. coli ClpX is a member of the Clp/Hsp100 family of ATPases that remodel multi-component complexes and facilitate ATP-dependent protein degradation. Protein remodelers alter the biological activity of their substrates, ...

Glioblastoma (GBM) is the most common and malignant form of brain cancer. After aggressive treatment, therapy resistant tumors inevitably recur. However, the molecular mechanisms underlying such resistance remain unclear. ...

Protein misfolding and aggregation is a ubiquitous challenge in biology and medicine. Among its many manifestations is age-onset cataract disease, the leading cause of vision loss. Cataracts arise from increased light ...

Each time a cell divides, the genome must be segregated equally between the two new daughter cells. To accomplish this, a specific region of each chromosome, termed the centromere, recruits the macromolecular kinetochore ...

The proteome of a cell needs to be constantly modified for protein quality control and to respond to environmental and developmental changes. Energy-dependent proteases are key to ensuring the proper composition of the ...

Throughout organismal development, precise three-dimensional organization of tissues is required for proper tissue function. These three-dimensional forms are generated by coordinated cell shape changes that induce global ...