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Browsing Department of Biology by Title
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(Massachusetts Institute of Technology, 1994)
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 1994)
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(Massachusetts Institute of Technology, 2004)The experiments presented in this thesis use mutation analysis, and study of the cells of mice with a deletion allele for the Trp53 gene, to explore both the regulation of p53, and its downstream functions mediated by ...
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Palindromes on the human X chromosome : testis-biased transcription, gene conversion and evolution (Massachusetts Institute of Technology, 2005)Recent genomic studies of the Y chromosome revealed massive, testis-specific palindromes that span 30% of the chromosome and are subject to gene conversion. We conducted studies to determine whether similar palindromes ...
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 1998)
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(Massachusetts Institute of Technology, 2002)
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(Massachusetts Institute of Technology, 1931)
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(Massachusetts Institute of Technology, 2010)Primary producers play a critical role in the oceanic food chain and the global cycling of carbon. The marine diazotroph Trichodesmium is a major contributor to both primary production and nitrogen fixation in the tropical ...
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(Massachusetts Institute of Technology, 1996)
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(Massachusetts Institute of Technology, 2011)Asymmetric cell division allows for better environmental adaptation and organismal complexity. Cells often divide by binary fission to form two identical daughter cells with similar developmental fates. However, a cell can ...
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(Massachusetts Institute of Technology, 2008)In eukaryotic cells, events such as DNA replication and mitosis must be carefully coordinated in the cell cycle to ensure that the entire genome is duplicated before cells undergo cell division. In particular, initiation ...
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(Massachusetts Institute of Technology, 1978)
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(Massachusetts Institute of Technology, 2012)The endoplasmic reticulum (ER) is responsible for the folding and processing of approximately one third of proteins in eukaryotic cells, and homeostasis in this compartment is tightly regulated. The Unfolded Protein Response, ...
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(Massachusetts Institute of Technology, 1995)
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(Massachusetts Institute of Technology, 2009)pRB is a member of the pocket protein family, which includes the closely related proteins p107 and p130. The pocket proteins are critical regulators of the cell cycle and function to restrain proliferation by controlling ...
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(Massachusetts Institute of Technology, 1995)
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Polyploidy in Saccharomyces cerevisiae leads to the loss of cell cycle control in stationary phase (Massachusetts Institute of Technology, 2003)Advances in genome sequencing and comparative genomics have uncovered ancient duplications in the genomes of many extant organisms. Evidence for large regional duplications is observed in eukaryotic organisms that include ...
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(Massachusetts Institute of Technology, 1997)
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