Browsing Department of Biology by Title
Now showing items 314-333 of 1048
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Farnesylation-dependent regulation of transcripts by PARP13
(Massachusetts Institute of Technology, 2015)PARP1 3 is a RNA-binding and catalytically inactive member of the poly(ADPribose) (PARP) family. PARP13 was first identified as a host antiviral factor that selectively binds to viral mRNAs and targets them for degradation ... -
Faunal biogeography, community structure, and genetic connectivity of North Atlantic seamounts
(Massachusetts Institute of Technology, 2008)The mechanisms of faunal dispersal across ocean basins are key unknowns toward understanding of the modern biogeography and biodiversity of deep-sea fauna. Seamounts are considered to play a defining role in faunal evolution, ... -
Feminization in common terns (Sterna hirunda) : relationship to persistent organic contaminants
(Massachusetts Institute of Technology, 1998) -
Fibronectin splice isoforms in wound healing and vascular development
(Massachusetts Institute of Technology, 2002)Fibronectins are a large family of extracellular matrix proteins that regulate cell adhesion, migration, differentiation and survival. Different isoforms of fibronectin arise via alternative splicing of the transcript of ... -
Fine-scale ecological dynamics of closely related marine microbes
(Massachusetts Institute of Technology, 2016)Microbial dynamics in the environment are major drivers of global biogeochemical cycles; hence there is great interest in characterizing their rates and causes. While dynamics are affected by processes across many ... -
Flexibility and specificity of the interaction of MCL-1 with BIM BH3
(Massachusetts Institute of Technology, 2009)Interactions among proteins of the BCL-2 family regulate apoptosis - the process of programmed cell death. This thesis focuses on interactions between anti-apoptotic BCL-2 proteins and BH3 peptides derived from pro-apoptotic ... -
Flow cytometry quantitation of dopamine receptor D2 loss as a sensitive measure of Huntington's Disease progression in mouse neurons
(Massachusetts Institute of Technology, 2013)Mouse models of Huntington's Disease (HD) are often used for testing potential therapeutic compounds. These experiments require substantial investments in time and resources, and have yet to produce any intervention that ... -
A flow cytometry-based method for gene expression profiling of CNS cell types
(Massachusetts Institute of Technology, 2014)In this thesis, I present a technique for profiling gene expression of specific cell types in the central nervous system (CNS), called fluorescence activated nuclei sorting (FANS). FANS utilizes flow cytometry to isolate ... -
The folding, assembly, and intracellular transport of murine class I major histocompatibility complex heavy chains
(Massachusetts Institute of Technology, 1997) -
Folding, stability and aggregation of the long-lived eye lens protein human gamma D crystallin
(Massachusetts Institute of Technology, 2006)Human [gamma]D crystallin (H[gamma]D-Crys) is a monomeric, two domain, primarily P-sheet protein found in high concentrations in the human eye lens. H[gamma]D-Crys and other crystallins are found in insoluble protein ... -
Form and function of Poly(A) tails
(Massachusetts Institute of Technology, 2020)Central to mRNA metabolism is the poly(A)-tail, a stretch of adenosine nucleotides at the mRNA 3' end. In this dissertation, I investigate the role of the tail in the dynamics of mRNA decay, and describe the predominant ... -
Form, function and flow in the plankton : jet propulsion and filtration by pelagic tunicates
(Massachusetts Institute of Technology, 2010)Trade-offs between filtration rate and swimming performance among several salp species with distinct morphologies and swimming styles were compared. Small-scale particle encounter at the salp filtering apparatus was also ... -
The formation and function of the brain ventricular system
(Massachusetts Institute of Technology, 2012)The brain ventricular system is composed of a highly conserved set of cavities that contain cerebrospinal fluid (CSF), a protein-rich fluid essential for brain function. However, little is known about the function of ... -
The formulation of a low-cost food mixture which would correct American dietary deficiencies
(Massachusetts Institute of Technology, 1940) -
Function and regulation of PARP13 binding to cellular RNA
(Massachusetts Institute of Technology, 2015)Poly(ADP-ribose) polymerase-13 (PARP13) is a member of the PARP family of proteins - enzymes that use NAD+ to synthesize a posttranslational protein modification called poly(ADP-ribose) (PAR). PARPs function in multiple ... -
Function and regulation of poly(A)-tail length
(Massachusetts Institute of Technology, 2014)Poly(A) tails are found at the 3' ends of nearly all eukaryotic messenger RNAs (mRNAs) and long non-coding RNAs. The presence of a poly(A) tail promotes translation and inhibits decay of an mRNA, with both effects mediated ... -
The function of E2F6 in the Polycomb complex
(Massachusetts Institute of Technology, 2005)The E2F family of transcription factors are known cell cycle regulators that function at the G1/S transition. Unlike other E2Fs, E2F6 does not activate transcription and is not regulated by pocket protein binding. Instead, ... -
Functional analyses of mitotic microtubule-binding complexes
(Massachusetts Institute of Technology, 2018)Mitosis is the process by which a single cell divides to form two identical daughter cells. Each daughter cell must inherit a full complement of the genetic material. Thus, a critical aspect of mitosis is the faithful ... -
Functional analysis of K-ras in the mouse by gene targeting
(Massachusetts Institute of Technology, 1996) -
Functional analysis of the histone variant H2A.Z during lineage commitment
(Massachusetts Institute of Technology, 2014)remained enigmatic. In this thesis, we dissect the role of H2A.Z during lineage commitment. In particular, we focused on the Polycomb-mediated mono-ubiquitylation of H2A.Z. We found that this modification regulates the ...
