Browsing Department of Biology by Title
Now showing items 575-594 of 1048
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The Major Histocompatibility Complex (MHC) and the proteasome-ubiquitin pathway in T cell development
(Massachusetts Institute of Technology, 2002)The essential role of classical MHC molecules in T cell development as well as the proteasome role in antigen processing for MHC-mediated antigen presentation to T cells is well established. However, the contribution of ... -
Mammalian gene regulation through the 3' UTR
(Massachusetts Institute of Technology, 2008)The untranslated region (UTR) at the 30 end of a mammalian mRNA is typically rich with regulatory motifs that influence the stability, localization, translation and other properties of the message. We explored two classes ... -
Mammalian sex determination : appraising the role of the autosomes
(Massachusetts Institute of Technology, 1995) -
Mapping the core regulatory circuitry of embryonic stem cells
(Massachusetts Institute of Technology, 2008)Embryonic stem (ES) cells are of tremendous biological interest because they have the capacity, termed pluripotency, to generate any cell type of the adult organism. Our lab is interested in understanding the genetic ... -
Mapping the therapy resistance landscapes of acute leukemias using in vivo functional genomics
(Massachusetts Institute of Technology, 2020)The recurrence of therapy resistant disease remains an intractable problem in oncology clinical care. To address this issue, investigators have traditionally focused on elucidating cell-intrinsic mechanisms that render ... -
Marine microbial intact polar diacylglycerolipids and their application in the study of nutrient stress and bacterial production
(Massachusetts Institute of Technology, 2013)Intact polar diacylglycerolipids (IP-DAGs) were used to study microbial dynamics in the surface ocean. IP-DAGs from surface ocean seawater were quantified using high performance liquid chromatography-mass spectrometry ... -
Mark-recapture statistics and demographic analysis
(Massachusetts Institute of Technology, 2002)Mark-recapture analysis of populations is becoming an important tool in population biology. Mark-recapture methods can be used to estimate transition probabilities among life-stages from capture histories of marked individuals ... -
Maternal environment and offspring physiology : the inheritance of information across a generation
(Massachusetts Institute of Technology, 2017)From the 4th century BC until the late 19th century AD philosophers and biologists ranging from Hippocrates to Charles Darwin hypothesized that information about the environment could be passed from parents to progeny. ... -
Measurement of in situ protein concentrations in lymphatic capillaries by ultrasoft X-ray microscopy
(Massachusetts Institute of Technology, 1969) -
Mechanism and consequences of Mu transpososome remodeling by the ClpX chaperone
(Massachusetts Institute of Technology, 2003)E. coli ClpX is a member of the Clp/Hsp100 family of ATPases that remodel multi-component complexes and facilitate ATP-dependent protein degradation. Protein remodelers alter the biological activity of their substrates, ... -
Mechanism and importance of Mcm2-7 double-hexamer formation during DNA replication initiation
(Massachusetts Institute of Technology, 2019)All cells must duplicate their genome completely and accurately in each cell cycle. Thus, DNA replication is a highly-regulated multi-step process that ensures the genome is duplicated only once per cell cycle. In eukaryotic ... -
Mechanism and specificity of bacterial two-component signaling systems
(Massachusetts Institute of Technology, 2010)Bacterial two component signaling (TCS) systems are the predominant means by which bacteria sense and respond to external signals. These systems represent a large family of paralogous proteins; often hundreds of the histidine ... -
Mechanism of acquired temozolomide resistance in glioblastoma
(Massachusetts Institute of Technology, 2014)Glioblastoma (GBM) is the most common and malignant form of brain cancer. After aggressive treatment, therapy resistant tumors inevitably recur. However, the molecular mechanisms underlying such resistance remain unclear. ... -
Mechanism of active substrate delivery by the AAA+ protease adaptor CIpS
(Massachusetts Institute of Technology, 2015)AAA+ molecular machines power myriad cellular processes including protein degradation, microtubule severing, membrane fusion, and initiation of DNA replication. Protein quality control in all organisms involves deployment ... -
Mechanism of aggregation of oxidation-mimicking mutants of human [gamma]D-crystallin
(Massachusetts Institute of Technology, 2016)Protein misfolding and aggregation is a ubiquitous challenge in biology and medicine. Among its many manifestations is age-onset cataract disease, the leading cause of vision loss. Cataracts arise from increased light ... -
The mechanism of chromosome segregation : genetics and cytology of the Drosophila mutants Dub, mei-S332 and ord
(Massachusetts Institute of Technology, 1997) -
Mechanism of DNA chain initiation by the dnaG protein of Escherichia coli
(Massachusetts Institute of Technology, 1981) -
Mechanism of Mcm10 function during DNA replication
(Massachusetts Institute of Technology, 2017)All life needs to replicate its genome completely and do so with limited errors. In eukaryotic cells, DNA replication is accomplished by a multi-stage process involving numerous protein assemblies. The core component of ... -
Mechanisms for maintaining genomic integrity during chromosome segregation in budding yeast
(Massachusetts Institute of Technology, 2009)Maintaining genomic integrity is crucial for an organism's fitness and survival. Regulation of chromosome segregation requires complex surveillance mechanisms that vary for different loci within the genome. This thesis ... -
Mechanisms for the propagation and recognition of human centromeres
(Massachusetts Institute of Technology, 2016)Each time a cell divides, the genome must be segregated equally between the two new daughter cells. To accomplish this, a specific region of each chromosome, termed the centromere, recruits the macromolecular kinetochore ...
