Browsing Department of Biology by Title
Now showing items 1-20 of 1008
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2', 3' isomeric specificity at the C-C-A end of tRNA during aminoacylation and protein synthesis.
(Massachusetts Institute of Technology, 1975) -
3D chromosome structure and chromatin proteomics
(Massachusetts Institute of Technology, 2016)The selective interpretation of the genome through transcription enables the production of every cell type's distinct gene expression program from a common genome. Transcription takes place within, and is controlled by, ... -
The 5' inositol phosphatase SHIP2 regulates EGF-elicited protrusion in MTLn3 cells
(Massachusetts Institute of Technology, 2010)In metastatic cancer, cells must be able to migrate from their original environment, move through the blood or lymphatic system, and colonize a distant organ. Mena, a member of the Ena/VASP family of proteins, is upregulated ... -
Aberrant Ras/MAPK signaling in skeletal development
(Massachusetts Institute of Technology, 2013)The Mitogen-activated protein kinase(MAPK) signaling pathway has been studied intensively in the context of neoplastic transformation. Other studies have focused on the roles of this pathway during development and have ... -
Acoustic classification of zooplankton
(Massachusetts Institute of Technology, 1998) -
Adhesion-GPCRs in cancer progression and metastasis
(Massachusetts Institute of Technology, 2016)Adhesion-GPCRs, a novel family of G protein-coupled receptors (GPCRs), are characterized by an extended extracellular region linked to a seven-pass transmembrane moiety via GPCR proteolytic site (GPS)-containing stalk ... -
Adult demography and larval processes in coastal benthic populations : intertidal barnacles in Southern California and Baja California
(Massachusetts Institute of Technology, 2005)The geographic distribution and dynamics of coastal benthic populations are shaped by physical - biological interactions affecting larval dispersal and the demography of juvenile and adult individuals. This thesis focused ... -
Advances in measurements of particle cycling and fluxes in the ocean
(Massachusetts Institute of Technology, 2013)The sinking flux of particles is an important removal mechanism of carbon from the surface ocean as part of the biological pump and can play a role in cycling of other chemical species. This work dealt with improving methods ... -
Age, movements, and feeding ecology of northwest Atlantic white sharks estimated from ecogeochemical profiles in vertebrae
(Massachusetts Institute of Technology, 2014)White sharks (Carcharodon carcharias) are highly migratory, ecologically important, vulnerable, and understudied marine predators. Ecogeochemistry, which takes advantage of natural variations in chemical signatures recorded ... -
AGO2 in overexpression exhibits oncogenic functions KrasG̳1̳2̳D̳ -associated mouse tumor models
(Massachusetts Institute of Technology, 2018)Cancer is a disease of normal healthy cells that have accumulated genetic aberrations that contribute to uncontrolled cell divisions. Generally, cancer cells have acquired gain of function mutations in oncogenes that ... -
Alexandrium catenella cyst dynamics in a coastal embayment : temperature dependence of dormancy, germination, and bloom initiation
(Massachusetts Institute of Technology, 2017)Blooms of the dinoflagellate Alexandrium catenella cause paralytic shellfish poisoning syndrome and present an expanding public health threat. They are inoculated through the germination of benthic cysts, a process regulated ... -
Allosteric activation of periplasmic HtrA proteases
(Massachusetts Institute of Technology, 2015)Escherichia coli responds to outer-membrane stress using a signaling cascade initiated when DegS, an HtrA-family periplasmic protease, cleaves RseA, a transmembrane anti-sigma factor, causing downstream release of the ... -
Alternatively spliced isoforms of Fibronectin, Tenascin-R and other potential players in early vasculogenesis
(Massachusetts Institute of Technology, 2019)The absence of both the EIIIA and EIIIB domains of fibronectin (FN) has been shown to negatively affect blood vessel formation and maintenance. Vascular defects have been observed in the yolk sacs of EIIIA/B double-null ... -
Amino acid recognition by a Class I tRNA synthetase
(Massachusetts Institute of Technology, 1996) -
Amino acid regulation of mTORC1
(Massachusetts Institute of Technology, 2013)Mammalian target of rapamycin complex I (mTORC1) is an atypical Ser/Thr kinase that regulates cellular and organismal growth. Accordingly, mTORC1 has substantial roles in regulating insulin sensitivity and lifespan, and ... -
Amino acid utilization by Aerobacter aerogenes and Escherichia coli
(Massachusetts Institute of Technology, 1938)A considerable amount of work has been done on the growth of A. aerogenes and E. coli in synthetic media, but little work has been undertaken on the utilization by these organisms of amino acids as comparative sources of ... -
Amino acids regulate the transcription, internal sorting, and intrinsic activity of the general amino acid permease (GAP1) in S. cerevisiae
(Massachusetts Institute of Technology, 2007)The high capacity general amino acid permease in Saccharomyces cerevisiae (GAP1) is regulated such that it actively imports amino acids into the cell from the extracellular medium only when internal amino acid levels are ... -
Amygdala circuits underlying valence-specific behaviors
(Massachusetts Institute of Technology, 2018)Threatening and rewarding stimuli evoke a set of distinct stereotyped behaviors, which can be categorized as negative and positive valence-related behaviors, respectively. The stereotypic nature of negative and positive ... -
Analyses of tau and radixin : two accessory proteins of the cytoskeleton in mammalian cells
(Massachusetts Institute of Technology, 1996) -
Analyses of the roles of the UmuDC proteins of E. coli in SOS mutagenesis and cell cycle regulation
(Massachusetts Institute of Technology, 1997)
