Browsing Biological Engineering - Ph.D. / Sc.D. by Title
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Browsing Biological Engineering - Ph.D. / Sc.D. by Title
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(Massachusetts Institute of Technology, 2013)The physical properties of a cell are manifestations of its most basic molecular and metabolic processes. In particular, size has been a sought metric, which can be difficult to ascertain with great resolution or for smaller ...
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(Massachusetts Institute of Technology, 2006)Osteoarthritis is characterized by synovial joint degeneration, and its cardinal pathological feature is degeneration and loss of the articular cartilage joint surface. While the aetiology of osteoarthritis is unknown, ...
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(Massachusetts Institute of Technology, 2006)Cells sense mechanical stimuli and respond by changing their phenotype, e.g. shape, gene expression, motility. This process, termed mechanotransduction, was investigated using computational and theoretical approaches, as ...
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(Massachusetts Institute of Technology, 2006)Alkyl-substituted anilines have been implicated as important etiological agents in human carcinogenesis. Specifically, 2,6-dimethylaniline (2,6-DMA), 3,5-dimethylaniline (3,5-DMA), and 3-ethylaniline (3EA) have been ...
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(Massachusetts Institute of Technology, 2009)One of the primary goals of cancer chemotherapy is the design of antitumor agents that achieve selective targeting of tumor cells while minimizing toxicity to normal tissues. We have synthesized a series of DNA damaging ...
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Metabolic and mechanistic exploration of a novel programmable genotoxicant against prostate cancer (Massachusetts Institute of Technology, 2009)Molecular design of novel pharmaceutical agents depends on a mechanistic paradigm. A library of compounds was designed to mimic some features of cisplatin that are believed to be in part responsible for its success as a ...
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A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death (Massachusetts Institute of Technology, 2011)Recent evidence demonstrates a correlative relationship between metabolic disorders and cancer prevalence. In addition, cholesterol lowering statins and the antidiabetes medication metformin both act as chemopreventive ...
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(Massachusetts Institute of Technology, 2008)Eight distinct nuclear shapes, or morphologies, have been discovered in human proto-organs and tumors, including bell-shaped nuclei with stem-like properties. These bell-shaped, or "metakaryotic," nuclei are abundant in ...
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(Massachusetts Institute of Technology, 2010)Analysis of single cells using flow cytometry techniques has created a wealth of knowledge about cellular phenomena that could not be obtained by population average measurements. As these techniques are integrated with ...
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(Massachusetts Institute of Technology, 2006)Many liver physiological and pathophysiological behaviors are not adequately captured by current in vitro hepatocyte culture methods. A 3D perfused microreactor previously demonstrated superior hepatic functional maintenance ...
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(Massachusetts Institute of Technology, 1998)
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Mitotic homologous recombination at engineered repeats in S. cerevisiae and in novel transgenic mice (Massachusetts Institute of Technology, 2003)Although homologous recombination provides an efficient means for repairing and tolerating DNA damage, mitotic recombination between misaligned sequences can lead to loss of genetic information (e.g. deletions, translocations ...
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(Massachusetts Institute of Technology, 2008)Molecular signaling systems allow cells to sense and respond to environmental stimuli. Quantitative modeling can be a valuable tool for evaluating and extending our understanding of signaling systems. In particular, studies ...
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(Massachusetts Institute of Technology, 2009)The primary motivation for this work is the manipulation of EGFR family signaling to influence regenerative responses of mesenchymal stem cells (MSC). Underlying the potential of regenerative medicine is the need to ...
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(Massachusetts Institute of Technology, 2005)Helicobacter hepaticus infection of A/JCr mice is a model of liver cancer resulting from chronic active inflammation. We monitored hepatic global gene expression profiles and correlated them to histological liver lesions ...
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(Massachusetts Institute of Technology, 2005)The objective of this work is to functionalize an existing polymer such that it better mimics natural tissue for tissue growth and regeneration. Numerous other processes have tried and accomplished this by non-specific ...
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(Massachusetts Institute of Technology, 2005)A multi-faceted approach was applied to the molecular design of substrates for the selective adhesion, proliferation and differentiation of connective tissue progenitors (CTPs) from human bone marrow aspirates. The basic ...
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(Massachusetts Institute of Technology, 2013)Receptor tyrosine kinases (RTKs) are critical regulators of cellular homeostasis in multicellular organisms. They influence cell proliferation, migration, differentiation, and transcriptional activation, among other ...
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(Massachusetts Institute of Technology, 1991)
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(Massachusetts Institute of Technology, 2013)There is increasing recognition that aberrant protein modifications play an important role in the pathophysiology of inflammation and oxidative stress in cells. We recently discovered that N⁶-formylation of lysine is an ...
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