Browsing Biological Engineering - Ph.D. / Sc.D. by Title
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Browsing Biological Engineering - Ph.D. / Sc.D. by Title
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(Massachusetts Institute of Technology, 2006)Many liver physiological and pathophysiological behaviors are not adequately captured by current in vitro hepatocyte culture methods. A 3D perfused microreactor previously demonstrated superior hepatic functional maintenance ...
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(Massachusetts Institute of Technology, 1998)
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Mitotic homologous recombination at engineered repeats in S. cerevisiae and in novel transgenic mice (Massachusetts Institute of Technology, 2003)Although homologous recombination provides an efficient means for repairing and tolerating DNA damage, mitotic recombination between misaligned sequences can lead to loss of genetic information (e.g. deletions, translocations ...
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(Massachusetts Institute of Technology, 2008)Molecular signaling systems allow cells to sense and respond to environmental stimuli. Quantitative modeling can be a valuable tool for evaluating and extending our understanding of signaling systems. In particular, studies ...
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(Massachusetts Institute of Technology, 2009)The primary motivation for this work is the manipulation of EGFR family signaling to influence regenerative responses of mesenchymal stem cells (MSC). Underlying the potential of regenerative medicine is the need to ...
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(Massachusetts Institute of Technology, 2005)Helicobacter hepaticus infection of A/JCr mice is a model of liver cancer resulting from chronic active inflammation. We monitored hepatic global gene expression profiles and correlated them to histological liver lesions ...
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(Massachusetts Institute of Technology, 2005)The objective of this work is to functionalize an existing polymer such that it better mimics natural tissue for tissue growth and regeneration. Numerous other processes have tried and accomplished this by non-specific ...
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(Massachusetts Institute of Technology, 2005)A multi-faceted approach was applied to the molecular design of substrates for the selective adhesion, proliferation and differentiation of connective tissue progenitors (CTPs) from human bone marrow aspirates. The basic ...
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(Massachusetts Institute of Technology, 2013)Receptor tyrosine kinases (RTKs) are critical regulators of cellular homeostasis in multicellular organisms. They influence cell proliferation, migration, differentiation, and transcriptional activation, among other ...
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(Massachusetts Institute of Technology, 1991)
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(Massachusetts Institute of Technology, 2013)There is increasing recognition that aberrant protein modifications play an important role in the pathophysiology of inflammation and oxidative stress in cells. We recently discovered that N⁶-formylation of lysine is an ...
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(Massachusetts Institute of Technology, 2012)This work investigates the roles that peptides play in the fields of antimicrobials, surface functionalization, carbon capture, and biocatalysis. The results demonstrate that peptides, sometimes dismissed for their lack ...
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(Massachusetts Institute of Technology, 2005)Micro- and nanofabrication approaches have dramatically changed our society through their use in microelectronics and telecommunication industries. These engineering tools are also useful for many biological applications ...
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(Massachusetts Institute of Technology, 2010)Solar energy provides an unparalleled promise to generate enormous amounts of clean energy. As the solar industry grows rapidly with a focus on power generation, new, but equally important challenges are emerging, including ...
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(Massachusetts Institute of Technology, 2001)The overall aim of this project was to investigate various cellular responses and toxic effects of nitric oxide, NO' and in vitro and in vivo. Nitric oxide gives rise to a complex spectrum of reactive species in oxygenated ...
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(Massachusetts Institute of Technology, 2008)The practical viability of biomolecule-nanostructure hybrids depends critically on the functional and structural stability of biomolecules in application environments. Noncovalent interactions of biochemical functional ...
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(Massachusetts Institute of Technology, 2007)Our understanding of glycosaminoglycan (GAG) biology has been limited by a lack of sensitive and efficient analytical tools designed to deal with these complex molecules. GAGs are heterogeneous and often sulfated linear ...
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(Massachusetts Institute of Technology, 2005)(cont.) kinetic studies. Moderate increases ([approximately]30%) in nucleobase deamination products were observed in the SJL mice bearing the RcsX tumor, but the biological meaning of these increases awaits studies of DNA ...
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(Massachusetts Institute of Technology, 2011)Mammalian noses can detect and distinguish an inestimable number of odors at minute concentrations. Four classes of G protein-coupled receptors (GPCRs) are responsible for this remarkable sensitivity: olfactory receptors ...
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(Massachusetts Institute of Technology, 2012)Tissue engineering is a potentially valuable tool for clinical treatment of diseases where host tissues or organs need to be replaced. Progression of engineering metabolically complex organs and tissues has been severely ...
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