Browsing Biological Engineering - Ph.D. / Sc.D. by Title
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Browsing Biological Engineering - Ph.D. / Sc.D. by Title
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Highly efficient Cas9 mediated transcriptional programming and delivery via Adeno-Associated Virus (Massachusetts Institute of Technology, 2017)The RNA-guided bacterial nuclease Cas9 can be reengineered as a programmable transcription factor by a series of modifications to the Cas9 protein and the direct fusion of a synthetic transcriptional activation domain (AD). ...
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(Massachusetts Institute of Technology, 2014)Studying biophysical properties of cells can provide insight into the metabolic mechanisms and regulation of cell cycle processes. Though size is considered to be a fundamental property of cell state, its measurement on a ...
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(Massachusetts Institute of Technology, 2016)The heterogeneity of individual cellular behavior in response to physical and chemical stimuli has raised increasing attention in many biological processes. There is great incentive in developing techniques for high ...
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(Massachusetts Institute of Technology, 2012)Human adaptation of avian influenza viruses pose an enormous public health challenge as the human population is predominantly naive to avian influenza antigens. As such, constant surveillance is needed to monitor the ...
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(Massachusetts Institute of Technology, 2013)Environmental bacteria display tremendous genetic diversity, but we are still learning how this diversity arises and relates to their wide range of habitats. Investigating how bacteria adapt helps us understand their ...
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Identification of malaria parasite-infected red blood cell aptamers by inertial microfluidics SELEX (Massachusetts Institute of Technology, 2015)Malaria kills over 500,000 people annually, the majority of whom are children under five years old in sub-Saharan Africa. This disease is caused by several parasite species, of which Plasmodium falciparum is associated ...
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(Massachusetts Institute of Technology, 2017)Reassortment is a reticulate evolutionary process that results in genome shuffling; the most prominent virus known to reassort is the influenza A virus. Methods to identify reassortant influenza viruses do not scale well ...
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(Massachusetts Institute of Technology, 2009)Tamoxifen resistance is the biggest problem in endocrine treatment against hormone receptor positive breast cancer patients. HER2 is a membrane receptor tyrosine kinase that is known to correlate with poor disease outcome ...
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(Massachusetts Institute of Technology, 2013)Vaccines have benefited global health by controlling or eradicating life threatening diseases. With better understanding of infectious diseases and immunity, more interest has been placed on stimulating mucosal immune ...
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(Massachusetts Institute of Technology, 2007)Recognition of polymicrobial infections is becoming important for understanding differential host responses to environmental exposures, vaccines, as well as therapeutics. Citrobacter rodentium is a well-characterized model ...
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(Massachusetts Institute of Technology, 2007)Mitotic homologous recombination is a critical pathway for the repair of DNA double-strand breaks and broken replication forks. Although homologous recombination is generally error-free, recombination between misaligned ...
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(Massachusetts Institute of Technology, 2016)Cytokine therapy can activate potent antitumor responses, yet collateral toxicity often limits dosages. Although immunocytokines have been designed with the intent to localize cytokine activity, systemic dose-limiting side ...
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(Massachusetts Institute of Technology, 2005)The extracellular matrix of tumors is a major barrier to the delivery of molecular medicine. We used fluorescence recovery after photobleaching combined with intravital microscopy to quantitate the transport properties of ...
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(Massachusetts Institute of Technology, 2007)Linkage disequilibrium studies have discovered few gene-disease associations for common diseases. The explanation has been offered that complex modes of inheritance govern risk for cancers, cardiovascular and cerebrovascular ...
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(Massachusetts Institute of Technology, 2011)The volume of protein structure data has grown rapidly over the past 30 years, leaving a wake of facts that still require explanation. We endeavored to answer a few open questions on the structure-function relationship of ...
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(Massachusetts Institute of Technology, 2016)Integrins are a family of heterodimeric cell surface receptors that are functionally important for cell adhesion, migration and proliferation. Certain integrins, especially those that are known to recognize the ...
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(Massachusetts Institute of Technology, 2005)Cancer is a leading cause of death in the world. Much work has been done to study the role of inflammation in carcinogenesis. One hypothesis suggests that inflammation causes oxidative stress that induces damage to cellular ...
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(Massachusetts Institute of Technology, 2009)This thesis describes the identification and characterization of a novel 'layer' of intrinsic non-genetic functional heterogeneity within the seemingly homogeneous naive CD8⁺ T cell population in their survival and ...
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(Massachusetts Institute of Technology, 2017)The DNA in every cell accrues nearly 100,000 lesions daily from both endogenous and exogenous sources. The accumulated damage, e.g. strand breaks and base lesions, can lead to mutations, cell death, and cancer if not ...
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(Massachusetts Institute of Technology, 2006)Ex vivo expansion of hematopoietic stem cells (HSCs) is a long-standing challenge faced by both researchers and clinicians. To date, no robust, efficient method for the pure, ex vivo expansion of human HSCs has been ...
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