Browsing Biological Engineering - Ph.D. / Sc.D. by Title
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Browsing Biological Engineering - Ph.D. / Sc.D. by Title
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(Massachusetts Institute of Technology, 2006)Endogenous and exogenous oxidants react with cellular macromolecules to generate a variety of electrophiles that react with DNA produce cytotoxic and mutagenic adducts. One source of such electrophiles is deoxyribose in ...
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Design principles of mammalian signaling networks : emergent properties at modular and global scales (Massachusetts Institute of Technology, 2008)This thesis utilizes modeling approaches rooted in statistical physics and physical chemistry to investigate several aspects of cellular signal transduction at both the modular and global levels. Design principles of ...
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(Massachusetts Institute of Technology, 2001)Overall cancer mortality rates have risen from about 4% of all deaths in the early 20th century to about 25% of all deaths by the end of the century in the United States. To assess any potential hypotheses for this increase ...
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(Massachusetts Institute of Technology, 2007)Human Hepatitis B virus (HBV) is the prototype member of the family Hepadnaviridae that consists of enveloped, partially double stranded DNA viruses that specifically target hepatocytes for viral replication. Although a ...
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(Massachusetts Institute of Technology, 2007)Citrobacter rodentium is a naturally occurring murine bacterial pathogen which is used to model human diarrheagenic E. coli (EPEC and EHEC) infections in mice. C. rodentium causes colonic hyperplasia and a variable degree ...
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(Massachusetts Institute of Technology, 2004)Understanding the hepatotoxicity of drugs and chemicals is essential for progress in academic research, medical science and in the development of new pharmaceuticals. Studying hepatotoxicity in vitro is a challenging task ...
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(Massachusetts Institute of Technology, 2004)Deoxyribose oxidation in DNA forms strongly electrophilic terminal blocking groups and abasic sites capable of stopping polymerases, forming DNA-protein crosslinks and nucleobase adducts. These threats to the genetic ...
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(Massachusetts Institute of Technology, 2012)Upon exposure to environmental cues, protein modifications form a complex signaling network that dictates cellular response. In this thesis, we develop methods for using continuous logic-based models to aide our understanding ...
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(Massachusetts Institute of Technology, 2007)Ligand binding to cell surface receptors initiates a cascade of signaling events regulated by dynamic phosphorylation on a multitude of pathway proteins. Quantitative features, including intensity, timing, and duration of ...
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(Massachusetts Institute of Technology, 2004)Complex carbohydrates such as the heparin/heparan sulfate glycosaminoglycans (HSGAGs) and the asparagine linked glycans (N-glycans) have emerged as crucial components of many human biological systems. Both classes of ...
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(Massachusetts Institute of Technology, 2008)Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with diagnostics and treatments that are ineffective at stopping the progression. This thesis examines new ways of both diagnosing and treating ALS, including ...
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(Massachusetts Institute of Technology, 2006)The continued success of protein therapeutics has put a strain on industry's ability to meet the large demand. Creating a more productive expression host for the manufacture of these proteins is a potential solution. ...
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(Massachusetts Institute of Technology, 2012)Many major human oncogenes contribute to cancer in large part by activating the mitogenactivated protein kinases (MAPK) ERK1 and ERK2 (ERK). These kinases are critical in normal physiological processes from development to ...
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(Massachusetts Institute of Technology, 1997)
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(Massachusetts Institute of Technology, 1998)
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(Massachusetts Institute of Technology, 2011)Gastric cancer is the 2nd leading cause of cancer death worldwide and the 4th most commonly diagnosed cancer worldwide. Helicobacter pylori infection is the major risk factor of gastric cancer, and as such, this bacterium ...
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(Massachusetts Institute of Technology, 1998)
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(Massachusetts Institute of Technology, 2010)Functional brain imaging technologies seek to expand our understanding of intact neural systems. Present day functional MRI (fMRI) measures the delayed hemodynamic response that is indirectly associated with neural activity. ...
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(Massachusetts Institute of Technology, 2012)The importance and pervasiveness of naturally occurring regulation of RNA function in biology is increasingly being recognized. A common regulatory mechanism uses inducible protein-RNA interactions to shape diverse aspects ...
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(Massachusetts Institute of Technology, 2009)Monoclonal antibodies have emerged as a promising class of therapeutics for the treatment of human disease, and in particular human cancer. While multiple mechanisms contribute to antibody efficacy, the engagement and ...
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